Serum pepsinogen II is a better diagnostic marker in gastric cancer
Serum pepsinogen II is a better diagnostic marker in gastric cancer
复制标题
血清胃蛋白酶原 II 是胃癌更好的诊断标志物
DOI：
10.3748/wjg.v18.i48.7357
复制
发表时间：
2012-12-28
影响因子：
4.3
通讯作者：
Jiang, Jing
中科院分区：
文献类型：
--
作者：
Cao, Xue-Yuan;Jia, Zhi-Fang;Jiang, Jing
目的：为探讨胃癌的筛查指标，我们评估了胃癌与血清胃蛋白酶原（PGs）的关系。方法：受试者包括450例胃癌患者，111例胃萎缩患者和961名健康对照者。血清抗幽门螺杆菌（H.采用酶联免疫吸附试验（ELISA）检测血清IgG、PG I和PG II。经胃镜检查及组织病理学检查确诊为胃萎缩及胃癌。采用多因素Logistic回归分析计算优势比和95%CI。中国东北地区幽门螺杆菌感染率仍然很高。H.胃癌组和胃萎缩组pylori IgG阳性率分别为69.1%和75.7%，明显高于对照组的49.7%（P < 0.001）。更高水平的PG II（15.9 μ g/L和13.9 μ g/L vs 11.5 μ g/L，P < 0.001）和较低的PG I / PG II比值（5.4和4.6 vs 8.4，P < 0.001），而血浆PG I浓度与胃癌发病风险无相关性（P = 0.537）。多因素Logistic回归分析显示，H. pylori感染和萎缩性胃炎是胃癌的独立危险因素。血浆PG I /PG H比值降低与胃萎缩和胃癌的风险增加相关。此外，血浆PG II水平与H显着相关。结论：血清PG Ⅱ浓度和PG Ⅰ/PG 11比值可作为H.幽门感染性胃病PG 11与胃癌风险独立相关。(C)2012年百世登。All rights reserved.
AIM: To investigate screening makers for gastric cancer, we assessed the association between gastric cancer and serum pepsinogens (PGs).METHODS: The subjects comprised 450 patients with gastric cancer, 111 individuals with gastric atrophy, and 961 healthy controls. Serum anti-Helicobacter pylori (H. pylon) immunoglobulin G (IgG), PG I and PG II were detected by enzyme-linked immunosorbent assay. Gastric atrophy and gastric cancer were diagnosed by endoscopy and histopathological examinations. Odds ratios and 95%CIs were calculated using multivariate logistic regression.RESULTS: Rates of H. pylori infection remained high in Northeastern China. Rates of H. pylori IgG positivity were greater in the gastric cancer and gastric atrophy groups compared to the control group (69.1% and 75.7% vs 49.7%, P < 0.001). Higher levels of PG II (15.9 mu g/L and 13.9 mu g/L vs 11.5 mu g/L, P < 0.001) and lower PG I / PG II ratio (5.4 and 4.6 vs 8.4, P < 0.001) were found in patients with gastric cancer or gastric atrophy compared to healthy controls, whereas no correlation was found between the plasma PG I concentration and risk of gastric cancer (P = 0.537). In addition, multivariate logistic analysis indicated that H. pylori infection and atrophic gastritis were independent risk factors for gastric cancer. Lower plasma PG I /PG H ratio was associated with higher risks of atrophy and gastric cancer. Furthermore, plasma PG II level significantly correlated with H. pylori-infected gastric cancer.CONCLUSION: Serum PG II concentration and PG I /PG 11 ratio are potential biomarkers for H. pylori-infected gastric disease. PG 11 is independently associated with risk of gastric cancer. (C) 2012 Baishideng. All rights reserved.