Relation of D-dimer levels of COVID-19 patients with diabetes mellitus.
Relation of D-dimer levels of COVID-19 patients with diabetes mellitus.
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DOI：
10.1016/j.dsx.2020.09.035
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Singh AR
中科院分区：
文献类型：
--
作者：
Mishra Y;Pathak BK;Mohakuda SS;Tilak TVSVGK;Sen S;P H;Singh R;Singh AR
糖尿病是严重COVID-19感染患者的常见合并症，预后较差。在COVID-19患者中已证实了高凝状态伴D-二聚体水平升高。本研究旨在研究COVID-19感染患者中糖尿病患者与非糖尿病患者的D-二聚体水平。在这项观察性研究中，98名患有COVID-19感染的中度和重度患者被纳入一家专门的COVID医院。研究组分为糖尿病患者和非糖尿病患者。在两组中测量峰值D-二聚体，并使用适当的统计学检验进行比较。在我们的研究中，糖尿病患者的D-二聚体峰值水平为1509 ± 2420 ng/mL（平均值± SD），非糖尿病患者为515 ± 624 ng/mL（平均值± SD）。糖尿病患者的D-二聚体水平较高，具有统计学意义。这项研究显示，COVID-19糖尿病患者的D-二聚体水平显著较高。因此，COVID-19感染合并糖尿病可能更容易导致高凝状态，预后更差。然而，这些发现的临床意义需要在进一步的研究中看到。患有糖尿病的COVID-19患者的疾病水平更严重。糖尿病患者在COVID-19中的D-二聚体水平较高。D-二聚体是糖尿病患者中COVID-19严重程度的有价值的生物标志物。
Diabetes is a frequent comorbidity in patients with Severe COVID-19 infection associated with a worse prognosis. Hypercoagulability with elevation in D-dimer levels has been demonstrated in patients with COVID-19. This study aims to study D-dimer levels in people with diabetes compared to those without diabetes among patients with COVID-19 infection. In this observational study 98 moderate and severely ill patients with COVID-19 infection were included at a dedicated COVID hospital. The study group was divided into patients with diabetes and without diabetes. Peak D-dimer was measured in both the groups and compared using appropriate statistical tests. In our study peak D-dimer levels were 1509 ± 2420 ng/mL (Mean ± SD) in people with diabetes and 515 ± 624 ng/mL (Mean ± SD) in patients without diabetes. Patients with diabetes had higher D-dimer levels which were statistically significant. This study shows COVID-19 patients with diabetes had significantly higher D-dimer levels. Therefore, it is possible that COVID-19 infection with diabetes is more likely to cause hypercoagulable state with a worse prognosis. However clinical implications of these findings will need to be seen in further studies. Patients of COVID-19 with diabetes had more severe disease levels. People with diabetes had higher D-dimer levels in COVID-19. D-dimer is a valuable biomarker of severity of COVID-19 in patients of diabetes.
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