Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients
Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients
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DOI：
10.1136/jcp.2010.075507
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发表时间：
2010-08-01
影响因子：
3.4
通讯作者：
Schuler, Christopher M.
中科院分区：
文献类型：
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作者：
Lash, Richard H.;Genta, Robert M.;Schuler, Christopher M.
背景和目的无蒂锯齿状腺瘤（SSA）被认为是微卫星不稳定腺癌的前体。本研究试图根据一个大型队列的流行病学来估计SSA的进展率，并确定与其他结直肠polyps.Methods的关系，Caris Diagnostics从179 111例患者的290 810份结肠镜标本中生成的病理报告使用计算机算法进行了分析。在2139例患者（54%为女性）的2416份标本中鉴定出。SSA+/-的分布为：右侧（81.2%）;左侧（11.2%）;右侧和左侧（3.2%）;未指明（4.3%）。1816例（85%）无异型增生（SSA-），257例（12%）低度异型增生（SSA-LD），45例（2%）高度异型增生（SSA-HD）和21例（1%）腺癌（SSA-CA）。几乎所有组之间的中位年龄差异显著（SSA-=61岁vs SSA-LD 66岁（p
Background and aims Sessile serrated adenomas (SSAs) are recognised as precursors to microsatellite unstable adenocarcinomas. This study attempts to estimate the progression rate of SSAs based upon the epidemiology of a large cohort as well as identify relationships to other colorectal polyps.Methods Pathological reports generated at Caris Diagnostics from 290 810 colonoscopic specimens on 179 111 patients were analysed using computerised algorithms.Results SSAs with or without dysplasia/carcinoma (SSA+/-) were identified in 2416 specimens from 2139 patients (54% women). The distribution of SSA+/- was: right-sided (81.2%); left-sided (11.2%); both right- and left-sided (3.2%); not specified (4.3%). There were 1816 (85%) patients without dysplasia (SSA-), 257 (12%) with low-grade dysplasia (SSA-LD), 45 (2%) with high-grade dysplasia (SSA-HD) and 21 (1%) with adenocarcinoma (SSA-CA). The difference in median age between almost all groups was significant (SSA-=61 years versus SSA-LD 66 years (p