Protists as opportunistic pathogens: Public health impact in the 1990s and beyond
Protists as opportunistic pathogens: Public health impact in the 1990s and beyond
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DOI：
10.1111/j.1550-7408.2000.tb00004.x
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发表时间：
2000-01-01
影响因子：
2.2
通讯作者：
Dykewicz, CA
中科院分区：
文献类型：
--
作者：
Kaplan, JE;Jones, JL;Dykewicz, CA
原生生物（原生动物和真菌）在人类免疫缺陷病毒（HIV）感染者和器官移植接受者（两个免疫功能低下的人群在过去二十年中急剧增加）中作为机会性病原体变得越来越突出。卡氏肺囊虫肺炎仍然是美国艾滋病毒感染者中最常见的严重机会性感染（OI），经常发生在以前没有接受过医疗护理的人群中。弓形虫病、隐球菌病、隐孢子虫病和等孢子虫病经常发生在发展中国家的艾滋病毒感染者中。念珠菌病和曲霉菌病是器官移植受者常见的oi。随着这些免疫抑制患者群体在世界范围内的不断扩大，由原生病原体引起的新的oi可能会出现。
Proist organisms (protozoa and fungi) have become increasingly prominent as opportunistic pathogens among persons infected with human immunodeficiency virus (HIV) and among organ transplant recipients-two immunocompromised populations that have increased dramatically in the past two decades. Pneumocystis carinii pneumonia continues to be the most common serious opportunistic infection (OI) among HIV-infected persons in the United States, occurring frequently among persons not previously receiving medical care. Toxoplasmosis, cryptococcosis, cryptosporidiosis, and isosporiasis occur frequently in HIV-infected persons in the developing world. Candidiasis and aspergillosis are common OIs in organ transplant recipients. As these populations of immuno-suppressed patients continue to expand worldwide new OIs caused by protist pathogens are likely to emerge.