Trichuris sp and Strongyloides sp Infections in a Free-Ranging Baboon Colony
Trichuris sp and Strongyloides sp Infections in a Free-Ranging Baboon Colony
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DOI：
10.1645/ge-2493.1
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发表时间：
2012-02-01
影响因子：
1.3
通讯作者：
Anderson, T. J. C.
中科院分区：
文献类型：
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作者：
Anderson, J.;Upadhayay, R.;Anderson, T. J. C.
2003年10月和2004年4月，在圣安东尼奥西南国家灵长类动物研究中心，我们对伊维菌素治疗前和治疗后6个月感染大型自由生活狒狒群的寄生虫进行了横断面调查。鞭虫属是存在的主要物种，在两次调查中感染了79%和69%的个体动物，粪便卵计数（FEC）高达60，200个卵/g（epg）（2003年10月平均值= 1，235，2004年4月平均值= 1，256）。各年龄组的流行率保持相当稳定，15岁动物的感染强度最高< 1 or >，与人类中观察到的模式相反，学龄儿童感染最严重。还鉴定了类圆线虫属，但种属身份仍不确定。小亚基核糖体DNA序列不同于发表的序列在多个网站的类圆线虫fuelleborni，但居住在一个单系群与其他类圆线虫物种与92%的自举支持。这可能反映了最近从本地宿主获得的，或者S. Fuelleborni是不正确的。广泛感染2线虫属在自由放养狒狒殖民地，是一个重要的来源，在人群中的发病率提供了一个有用的模型系统的流行病学，控制，病理学和遗传学的工作，这些寄生虫的宿主物种是生理学，免疫学和遗传学上类似于人类。
We conducted cross-sectional surveys of parasites infecting a large free-living colony of baboons at the Southwest National Primate Research Center in San Antonio in October 2003 and April 2004, immediately before, and 6 mo after, treatment with ivermectin. Trichuris sp. was the predominant species present, infecting 79 and 69% of individual animals in the 2 surveys, with fecal egg counts (FEC) of up to 60,200 eggs per g (epg) (mean = 1,235 in October 2003 and 1,256 in April 2004). Prevalence remained fairly stable across age groups, and intensity was highest in animals < 1 or > 15 yr old, in contrast to patterns observed in humans, where school-age children show the heaviest infections. Strongyloides sp. was also identified, but the species identity remains uncertain. Small subunit ribosomal DNA sequences differed from published sequences of Strongyloides fuelleborni at multiple sites, but resided in a monophyletic group with other Strongyloides species with 92% bootstrap support. This may reflect a recent acquisition from a local host, or that the published sequence of S. fuelleborni is incorrect. Widespread infections with 2 nematode genera in a free-ranging baboon colony that are an important source of morbidity in human populations provide a useful model system for work on the epidemiology, control, pathology, and genetics of these parasites in a host species that is physiologically, immunologically, and genetically similar to humans.