The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus.
The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus.
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DOI：
10.1155/2021/9526701
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发表时间：
2021
影响因子：
4.3
通讯作者：
Ye S
中科院分区：
文献类型：
--
作者：
Zheng M;Wang X;Guo H;Fan Y;Song Z;Lu Z;Wang J;Zheng C;Dong L;Ma Y;Zhu Y;Fang H;Ye S
炎症和细胞因子风暴的诱导被认为在新冠肺炎中起着关键作用。本研究旨在探讨新冠肺炎住院患者糖代谢与炎症状态的关系。将71例新冠肺炎住院患者分为非糖尿病组、空腹血糖受损组和糖尿病组。与IFG组和NDM组相比，DM患者的平均住院天数明显缩短。DM组CD4+T细胞百分率高于NDM组，CD8+T细胞百分率低于NDM组。糖尿病组血清IL-6、IL-2、IL-10和干扰素-γ水平较非糖尿病组明显升高。DM组血清肿瘤坏死因子-α、IL-4、IL-2、IL-10和干扰素-γ水平显著高于IFG组。调整BMI后，NDM组与DM组的CD4+T细胞、CD4+/CD8+比值、IL-6、IL-10差异有统计学意义。总而言之，血糖水平升高的新冠肺炎患者促进了细胞因子谱和免疫反应。
The induction of inflammation and cytokine storm was proposed to play a critical role in COVID-19. This study is aimed at investigating the relationship between glucose metabolism and the inflammatory state of inpatients with COVID-19. 71 inpatients with COVID-19 were classified into nondiabetes mellitus (NDM) group, impaired fasting glucose (IFG) group, and diabetes mellitus (DM) group. The average hospitalization days were significantly shorter in DM patients when compared with patients in the IFG group and NDM group. CD4+ T cell percentage was higher while CD8+ T cells percentage was lower in the DM group than those in the NDM group. The serum levels of IL-6, IL-2, IL-10, and INF-γ in the DM group were upregulated when compared with those in the NDM group. The serum levels of TNF-α, IL-4, IL-2, IL-10, and INF-γ were significantly higher in the DM group than those in the IFG group. A significant difference was observed in CD4+ T cell, CD4+/CD8+ ratio percentage, IL-6, and IL-10 between the NDM group and DM group with adjusted BMI. In conclusion, COVID-19 patients with elevated glucose levels have promoted cytokine profiles and immune response.
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影响因子：
11.1
作者：
Van Wyngene L;Vandewalle J;Libert C
通讯作者：
Libert C
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
11.8
作者：
Qin, Chuan;Zhou, Luoqi;Tian, Dai-Shi
通讯作者：
Tian, Dai-Shi
DOI：
10.1186/cc12514
发表时间：
2013-03-06
期刊：
Critical care (London, England)
影响因子：
--
作者：
Marik PE;Bellomo R
通讯作者：
Bellomo R
影响因子：
20.1
作者：
Cameron AR;Morrison VL;Levin D;Mohan M;Forteath C;Beall C;McNeilly AD;Balfour DJ;Savinko T;Wong AK;Viollet B;Sakamoto K;Fagerholm SC;Foretz M;Lang CC;Rena G
通讯作者：
Rena G