Menstrual Phase and Depressive Symptoms Differences in Physiological Response to Nicotine Following Acute Smoking Abstinence
Menstrual Phase and Depressive Symptoms Differences in Physiological Response to Nicotine Following Acute Smoking Abstinence
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DOI：
10.1093/ntr/nts236
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发表时间：
2013-06-01
影响因子：
4.7
通讯作者：
Hatsukami, Dorothy
中科院分区：
文献类型：
--
作者：
Allen, Sharon S.;Allen, Alicia M.;Hatsukami, Dorothy
越来越多的证据表明抑郁症状和性激素与复发风险有关。然而，这些关联所涉及的具体机制仍然未知。这项随机交叉研究评估了急性戒烟后有或没有抑郁症状的女性吸烟者在月经阶段对尼古丁的生理反应。 纳入对象为年龄 1840 岁、月经周期规律、未服用外源激素或精神药物、报告每天吸 5 支烟的女性。参与者被分为 2 组：无抑郁症状（NDS；n 23）和抑郁症状（DS；n 24）。经过 4 天的生化验证戒烟后，参与者完成了卵泡 (F) 和黄体 (L) 阶段的 2 次实验室课程。参与者在时间 0 时使用尼古丁鼻喷雾剂，并在时间 1、5、10、20、30、45、60 和 90 分钟测量血压、心率和血清尼古丁。参与者 (n = 47) 年龄为 29.16.8 岁，平均每天吸 12.55.1 支香烟。与 DS 组相比，NDS 组在舒张压、心率和尼古丁最大浓度方面有更明显的月经期差异 (F > L) (p < .05)。这项研究观察到性激素和抑郁症状之间的相互作用，使得那些没有抑郁症状的人对尼古丁的生理反应有更大的月经期差异。这些数据为性激素在尼古丁生理反应中的作用提供了额外的支持，这可能在月经期对戒烟的影响中发挥作用。
Accumulating evidence has linked depressive symptoms and sex hormones to risk for relapse; however, the specific mechanisms involved in these associations remain unknown. This randomized crossover study assessed physiological response to nicotine by menstrual phase in female smokers with and without depressive symptoms following acute smoking abstinence.Females, ages 1840 years with regular menstrual cycles, not on exogenous hormones or psychotropic medications, who reported smoking 5 cigarettes/day were enrolled. Participants were stratified into 2 groups: no depressive symptoms (NDS; n 23) and depressive symptoms (DS; n 24). After 4 days of biochemically verified smoking abstinence, participants completed 2 laboratory sessions in the follicular (F) and luteal (L) phases. Participants used nicotine nasal spray at Time 0, and blood pressure, heart rate, and serum nicotine were measured at Time 1, 5, 10, 20, 30, 45, 60, and 90min.Participants (n 47) were 29.16.8 years old and smoked an average of 12.55.1 cigarettes/day. The NDS group had more pronounced menstrual phase differences (F > L) in diastolic blood pressure, heart rate, and maximum concentrations of nicotine compared with the DS group (p < .05).This study observed an interaction between sex hormones and depressive symptoms such that those without depressive symptoms had a greater menstrual phase difference in the physiological response to nicotine. These data offer additional support for the role of sex hormones in the physiological response to nicotine, which may play a role in menstrual phase effects on smoking cessation.