Age at menopause and cause-specific mortality in South Korean women: Kangwha Cohort Study
Age at menopause and cause-specific mortality in South Korean women: Kangwha Cohort Study
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DOI：
10.1016/j.maturitas.2006.11.004
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发表时间：
2007-04-20
期刊：
影响因子：
4.9
通讯作者：
Ohrr, Heechoul
中科院分区：
文献类型：
--
作者：
Hong, Jae Seok;Yi, Sang-Wook;Ohrr, Heechoul
目的：本研究的目的是探讨女性自然绝经年龄与全因和特定原因死亡率之间的关系。 方法：本研究使用了 1985 年至 2001 年随访的 Kangwha 队列的数据，特别是 55 岁或以上女性组 (n = 2658)。我们使用 Cox 比例风险模型计算了绝经年龄组的死亡率风险比，并调整了年龄、饮酒量、教育程度、首次生育年龄、自我认知健康水平、慢性疾病、婚姻伴侣、产次、初潮年龄、口服避孕药使用和高血压。结果：绝经年龄的平均（标准差）为 46.9（4.9）岁，中位年龄为 48 岁。调整相关变量后，早期绝经组（绝经<40岁）的总死亡风险比参考组（绝经45-49岁）高1.32倍（95%置信区间[CI]，1.05-1.66，p = 0.02）。对于早期绝经组，相对于参考组，心血管疾病和癌症死亡的调整后风险比分别为 1.53 (95% CI, 1.00-2.39, p = 0.04) 和 2.01 (95% CI, 1.06-3.82, p = 0.03)。 结论：通过这项研究，发现亚洲人和亚洲人的绝经年龄存在差异。白人女性和绝经年龄与死亡（尤其是由心血管疾病和癌症引起的死亡）之间的关系得到了验证。我们的研究是关于亚洲女性绝经年龄及其死亡风险的罕见研究之一，可以认为是有意义的。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Objective: The purpose of this study was to examine the relation between age at natural menopause and all-cause and cause-specific mortality among women.Methods: This study used the data of the Kangwha Cohort that was followed up from 1985 to 2001, in particular, for the group of 55 years or older women (n = 2658). We calculated the hazard ratio of mortality by the group of age at menopause using the Cox proportional hazards model with adjustment for age, alcohol consumption, education, age at first birth, self-cognitive health level, chronic disease, marital partner, parity, age at menarche, oral contraceptive use and hypertension.Results: The mean (standard deviation) age at menopause was 46.9 (4.9) years, and the median age was 48 years. After adjusting for the relevant variables, the risk of total death in the early menopause group (< 40 years at menopause) was 1.32 times higher than that of the reference group (45-49 years at menopause) (95% confidence interval [CI], 1.05-1.66, p = 0.02). For the early menopause group, relative to the reference group, the adjusted hazard ratios of death due to cardiovascular disease and cancer were 1.53 (95% CI, 1.00-2.39, p = 0.04) and 2.01 (95% CI, 1.06-3.82, p = 0.03), respectively.Conclusion: Through this study, the age at menopause was found to be different between Asian and Caucasian women and the association of age at menopause with death, particularly caused by cardiovascular disease and cancer, was validated. Our study is one of rare studies regarding the age at menopause of Asian women and their risk of mortality, which could be considered to be meaningful. (c) 2006 Elsevier Ireland Ltd. All rights reserved.