Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen
Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen
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DOI：
10.1021/nl060548p
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发表时间：
2006-08-09
期刊：
影响因子：
10.8
通讯作者：
Terrones, M.
中科院分区：
文献类型：
--
作者：
Carrero-Sanchez, J. C.;Elias, A. L.;Terrones, M.
在这份报告中，我们比较了纯碳多壁纳米管(MWNTs)和氮掺杂多壁碳纳米管(CNX)的毒理学效应。不同剂量的管子以不同的方式给小鼠：鼻腔、口服、气管内和腹膜内。我们发现，当MWNTs被注入小鼠的气管时，小鼠可能会因呼吸困难而死亡，具体取决于MWNTs的剂量。然而，CNX纳米管从未导致任何小鼠死亡。我们一直发现，与多壁碳纳米管相比，CNX纳米管对小鼠的耐受性要强得多。将极高浓度的CNX纳米管直接注入小鼠的气管只会引起肉芽肿性炎症反应。重要的是，所有其他给药途径都没有在任何接受治疗的小鼠身上引起痛苦或组织变化的迹象。因此，我们认为CNX纳米管比多壁碳纳米管或单壁碳纳米管的危害更小，可能更有利于生物应用。
In this report, we compare the toxicological effects between pure carbon multiwalled nanotubes (MWNTs) and N-doped multiwalled carbon (CNx) nanotubes. Different doses of tubes were administered in various ways to mice: nasal, oral, intratracheal, and intraperitoneal. We have found that when MWNTs were injected into the mice's trachea, the mice could die by dyspnea depending on the MWNTs doses. However, CNx nanotubes never caused the death of any mouse. We always found that CNx nanotubes were far more tolerated by the mice when compared to MWNTs. Extremely high concentrations of CNx nanotubes administrated directly into the mice's trachea only induced granulomatous inflammatory responses. Importantly, all other routes of administration did not induce signs of distress or tissue changes on any treated mouse. We therefore believe that CNx nanotubes are less harmful than MWNTs or SWNTs and might be more advantageous for bioapplications.