Genetics of mouse behavior: Interactions with laboratory environment
Genetics of mouse behavior: Interactions with laboratory environment
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DOI：
10.1126/science.284.5420.1670
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发表时间：
1999-06-04
期刊：
影响因子：
56.9
通讯作者：
Dudek, BC
中科院分区：
文献类型：
--
作者：
Crabbe, JC;Wahlsten, D;Dudek, BC
表现出特征性行为模式的小鼠品系对神经行为遗传学的研究至关重要。在几个近交系和一个无效突变体中研究了实验室环境可能的混杂影响，方法是：在三个实验室同时测试一组六种行为。仪器，测试协议，和许多环境变量严格等同。菌株在所有行为上都有显著差异，尽管标准化，但实验室之间的行为存在系统性差异。对于某些测试，遗传差异的大小取决于特定的测试实验室。因此，表征突变体的实验可能会产生特定实验室特有的结果。
Strains of mice;that:show characteristic patterns of behavior are critical for research in neurobehavioral genetics. Possible confounding influences of the Laboratory environment were studied in several inbred strains and one null mutant by:simultaneous testing in three Laboratories on a battery of six behaviors. Apparatus, test protocols, and many environmental variables were rigorously equated. Strains differed markedly in all behaviors, and despite standardization, there were systematic differences in behavior across Labs. For some tests, the magnitude of genetic differences depended upon the specific testing Lab.. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular Laboratory.