Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter
Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter
复制标题
DOI：
10.1148/radiology.216.2.r00au16351
复制
发表时间：
2000-08-01
期刊：
影响因子：
19.7
通讯作者：
McGowan, JC
中科院分区：
文献类型：
--
作者：
Catalaa, I;Grossman, RI;McGowan, JC
目的：研究复发-缓解期多发性硬化(MS)患者脑白质(NAWM)磁化传递比(MT)值的总体分布特征，验证NAWM磁化传递比直方图反映疾病进展的假设。材料和方法：对23例患者和25例健康志愿者进行常规和多层螺旋CT检查。与MT直方图参数比较的临床测试包括扩展残疾状态量表和行走指数。用T2加权磁共振图像计算病变负荷，并测量全脑和白质体积。结果：MS患者NAWM的MT直方图峰位置和平均MT比率明显低于对照组。在纵向研究中，随着病程的延长，直方图峰位置和平均MT比值向正常值方向移动。在后来的研究中发现的新病变的平均体积的26.5%被证明起源于NAWM，对应于直方图上“丢失”的像素。结论：包括纵向分析在内的NAWM的MT直方图分析可以提供有关病变形成的新的预后信息，并增加对疾病病程的了解。
PURPOSE: To investigate and characterize the global distribution of magnetization, transfer (MT) ratio values of normal-appearing white matter (NAWM) in patients with relapsing-remitting multiple sclerosis (MS) and test the hypothesis that the MT histogram for NAWM reflects disease progression. MATERIALS AND METHODS: Conventional and MT magnetic resonance (MR) Images were obtained in 23 patients and 25 healthy volunteers. Clinical tests for comparison with the MT histogram parameters included the Extended Disability Status Scale and the ambulation index. Lesion load calculated with T2-weighted MR images and whole-brain and white matter volumes were measured. RESULTS: The location of the MT histogram peak and the mean MT ratio for NAWM were significantly lower in patients with MS than in control subjects. In longitudinal studies, the histogram peak location and mean MT ratio shifted in the direction of normal values as the duration of disease increased. A mean of 26.5% of the volume of new lesions identified on the later studies were demonstrated to have originated in NAWM corresponding to "lost" pixels on the histogram. CONCLUSION: MT histogram analysis of NAWM, including longitudinal analysis, may provide new prognostic information regarding lesion formation and increase understanding of the course of the disease.