Paraneoplastic hyperpigmentation secondary to lung cancer resolving after chemotherapy.
Paraneoplastic hyperpigmentation secondary to lung cancer resolving after chemotherapy.
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DOI：
10.1097/00000421-199910000-00023
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发表时间：
1999-10
期刊：
影响因子：
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通讯作者：
M. Ozgüroğlu;V. Tahan;E. Ozgüroğlu;R. Ozaras;G. Demir
中科院分区：
文献类型：
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作者：
M. Ozgüroğlu;V. Tahan;E. Ozgüroğlu;R. Ozaras;G. Demir
新癌有时会产生远离肿瘤本身的症状，而没有任何直接的组织侵犯或肿瘤肿块。由肿瘤产生的蛋白质激素、其前体或细胞因子引起的症状和体征被定义为副肿瘤综合征。与原发性肺癌相关的副肿瘤综合征患者的临床特征范围从轻度全身性皮肤病到重度神经肌病。2由于其诊断往往是一个排除，它的识别可能是困难的或late.We提出一个非小细胞肺癌的情况下，广泛色素沉着，前2年的恶性诊断。色素沉着在联合化疗后消退，伴随着原发肿瘤的消退和瘙痒的缓解。
Neoplasms sometimes produce symptoms distant from the tumor itself without any direct tissue invasion or tumor mass. Symptoms and signs, caused by protein hormones, their precursors, or cytokines produced by the tumor are defined as paraneoplastic syndrome. 1 The spectrum of clinical features in patients with paraneoplastic syndromes associated with primary lung cancer ranges from mild systemic cutaneous disease to severe neuromyopathic disorders. 2 Because its diagnosis is often one of exclusion, its recognition may be difficult or late.We present a case of non–small-cell lung cancer with generalized hyperpigmentation, preceding the diagnosis of the patient’s malignancy by 2 years. Hyperpigmentation resolved after combination chemotherapy, accompanied by regression of primary tumor and relieving of itching.