CONTROL ANALYSIS OF TRANSIT-TIME FOR FREE AND ENZYME-BOUND METABOLITES - PHYSIOLOGICAL AND EVOLUTIONARY SIGNIFICANCE OF METABOLIC RESPONSE-TIMES
CONTROL ANALYSIS OF TRANSIT-TIME FOR FREE AND ENZYME-BOUND METABOLITES - PHYSIOLOGICAL AND EVOLUTIONARY SIGNIFICANCE OF METABOLIC RESPONSE-TIMES
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DOI：
10.1042/bj3080895
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发表时间：
1995-06-15
影响因子：
4.1
通讯作者：
KACSER, H
中科院分区：
文献类型：
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作者：
CASCANTE, M;MELENDEZHEVIA, E;KACSER, H
转运的对照分析为tau = sigma/J，以前考虑了与代谢物的游离池相比低酶浓度的限制[Melendez-Hevia，托雷斯，西西利亚和Kacser（1990）Biochem.J.265，195-202]。其中一个结论是，过渡时间相对于酶浓度的控制系数之和为-1。在这里，我们证明，如果考虑酶结合池（这在高酶浓度和高亲和力下很重要），总和在0和-1之间。两个稳定状态之间的过渡时间，这是常见的生理事件，主要是由涉及改变酶浓度的时间常数决定的。一些生理和进化方面进行了讨论。
Control analysis of transit as tau = sigma/J, has previously been considered with the contraint of low enzyme concentrations compared with free pools of metabolites [Melendez-Hevia, Torres, Sicilia and Kacser (1990) Biochem. J. 265, 195-202]. One of the conclusions was that the sum of the control coefficients of the transition time with respect to enzyme concentration was -1. Here we demonstrate that, if the enzyme-bound pools are taken into consideration (which would be important at high enzyme concentrations and high affinities), the sum lies between 0 and -1. The transition time between two steady states, which are frequent physiological events, in mainly governed by time constants involved in changing the enzyme concentrations. Some physiological and evolutionary aspects are discussed.