Extravascular lung water correlates multiorgan dysfunction syndrome and mortality in sepsis.
Extravascular lung water correlates multiorgan dysfunction syndrome and mortality in sepsis.
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DOI：
10.1371/journal.pone.0015265
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发表时间：
2010-12-16
期刊：
影响因子：
3.7
通讯作者：
Lin SM
中科院分区：
文献类型：
--
作者：
Chung FT;Lin HC;Kuo CH;Yu CT;Chou CL;Lee KY;Kuo HP;Lin SM
本研究旨在探讨血管外肺水指数（EVLWI）升高是否与脓毒症多器官功能障碍综合征（MODS）和死亡率相关。我们在一家三级医院的重症监护室设计了一项前瞻性队列研究。纳入了67例严重脓毒症患者。数据用于确定EVLWI与MODS发展和死亡率之间的相关性。这些联系通过多元逻辑回归、绘制受试者工作特征（ROC）曲线和斯皮尔曼检验来确定。第1天MODS患者的EVLWI水平（中位数（IQR），18（12.8-23.9）ml/kg，n = 38，p<0.0001）高于无MODS患者（中位数（IQR），12.4（7.9-16.3）ml/kg，n = 29），第3天MODS患者的EVLWI水平（中位数（IQR），17.8（11.2-22.8）ml/kg，n = 29，p = 0.004）高于无MODS患者（中位数（IQR），12.4（8.0-16.3）ml/kg，n = 29）。 EVLWI被用作ICU住院期间发生MODS的独立预测因素（比值比，1.6; p = 0.005; 95%置信区间，1.2 - 2.2）。 ROC曲线下面积显示EVLWI水平可预测ICU期间的MODS（0.866）和死亡率（0.881）。SOFA评分越高，术后第1天和第3天EVLWI的检出率越高（r = 0.7041，p<0.0001）和（r = 0.7732，p<0.0001）。 EVLWI水平升高与患者ICU期间MODS的发生和死亡率相关。此外，严重脓毒症肺损伤的新治疗方法的潜力可能会开发。
This study was designated to investigate whether increased extravascular lung water index (EVLWI) may correlate multiple organ dysfunction syndrome (MODS) and mortality in sepsis. We designed a prospective cohort study in an intensive care unit of a tertiary care hospital. Sixty-seven patients with severe sepsis were included. Data were used to determine an association between EVLWI and the development of MODS and mortality. These connections were determined by the multiple logistic regression, plotting the receiver operating characteristic (ROC) curve and by Spearman test. EVLWI levels were higher in MODS patients on day 1 (median (IQR), 18(12.8–23.9) ml/kg, n = 38, p<0.0001) than in those without (median (IQR), 12.4 (7.9–16.3) ml/kg, n = 29) and day 3 (median (IQR), 17.8 (11.2–22.8) ml/kg, n = 29, p = 0.004) than in those without (median (IQR), 12.4 (8.0–16.3) ml/kg, n = 29). EVLWI was used as an independent predictor of the development of MODS (odds ratio, 1.6; p = 0.005; 95% confidence interval, 1.2∼2.2) during ICU stay. The area under the ROC curve showed that EVLWI levels could predict MODS (0.866) and mortality (0.881) during ICU stay. Meanwhile, the higher of SOFA score, the more EVLWI was found on day 1 (r = 0.7041, p<0.0001) and day 3 (r = 0.7732, p<0.0001). Increased EVLWI levels correlates development of MODS and mortality during the patients' ICU stay. Further more, the potential of novel treatment in severe sepsis with lung injury may develop.
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影响因子：
8.8
作者：
ASTIZ, ME;DEGENT, GE;RACKOW, EC
通讯作者：
RACKOW, EC
DOI：
10.1016/j.ccell.2006.11.002
发表时间：
2007-03-01
影响因子：
1.5
作者：
Krau, Stephen D
通讯作者：
Krau, Stephen D
影响因子：
9.6
作者：
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通讯作者：
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影响因子：
8.8
作者：
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通讯作者：
SIBBALD, WJ
影响因子：
8.8
作者：
Angus, D C;Linde-Zwirble, W T;Pinsky, M R
通讯作者：
Pinsky, M R