Influence of sub-micron surface patterns on the deposition of model proteins during active filtration
Influence of sub-micron surface patterns on the deposition of model proteins during active filtration
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DOI：
10.1016/j.memsci.2013.05.060
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发表时间：
2013-10-01
影响因子：
9.5
通讯作者：
Ding, Yifu
中科院分区：
文献类型：
--
作者：
Maruf, Sajjad H.;Rickman, Melissa;Ding, Yifu
在这项研究中，研究了在活性过滤和简单吸附条件下，亚微米表面图案对模型蛋白质溶液(牛血清白蛋白)污垢的影响。使用纳米压印光刻技术，直接在商用聚醚砜超滤膜上形成表面图案，从而使截留分子量(MWCO)略有降低，但透过率与非印迹超滤膜相近，并显著提高了抗BSA污染的能力。采用反冲洗的分级过滤实验表明，印迹膜的渗透通量明显高于非印迹膜，这与UV-Vis测量结果一致，表明印迹膜上的蛋白质沉积较少。印迹膜抗污染性能的这种改善在不同的料液化学中普遍观察到，包括pH和离子强度的变化。从非过滤条件下的受控蛋白质吸附实验来看，观察到的蛋白质在印迹膜上的吸附减少可能与由于亚微米图案的存在而改变了流体动力学有关。(C)2013爱思唯尔B.V.保留所有权利。
In this study, the effects of sub-micron surface patterns on the fouling of a model protein solution (bovine serum albumin (BSA)), was investigated during active filtration and simple adsorption conditions. Surface patterns were created directly onto a commercial polyethersulfone ultrafiltration membrane using nanoimprint lithography, which resulted in a moderately reduced molecular mass cut-off (MWCO) but similar permeance as its non-imprinted counterpart as well as significantly improved resistance to BSA fouling. Staged filtration experiments, with backwash cleaning, revealed that the permeate flux of the imprinted membrane was considerably higher than that of the non-imprinted membrane, consistent with UV-vis measurements showing less protein deposition on the imprinted membranes. This improvement in anti-fouling characteristics for the imprinted membrane was universally observed for varying feed-solution chemistry including changes in both pH and ionic strength. From controlled protein-adsorption experiments under non-filtration conditions, it appears that the observed decrease in protein adsorption on the imprinted membranes is likely associated with altered hydrodynamics due to the presence of the sub-micron patterns. (C) 2013 Elsevier B.V. All rights reserved.