Pulp-dentin regeneration: current approaches and challenges
Pulp-dentin regeneration: current approaches and challenges
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DOI：
10.1177/2041731418819263
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发表时间：
2019-01-29
影响因子：
8.2
通讯作者：
Song, Minju
中科院分区：
文献类型：
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作者：
Jung, Chanyong;Kim, Sangwan;Song, Minju
根尖周炎的未成熟恒牙的再生根管治疗具有生物学优势，如牙齿稳态，增强免疫防御系统和功能性牙髓-牙本质复合体，以及临床优势，如促进牙根发育。目前，这种方法被认为是从使用材料修复到再生牙髓牙本质组织的范式转变。许多研究已经进行了关于干/祖细胞，支架，和生物分子，与牙髓组织工程。然而，临床前和临床研究已经清楚地揭示了当前血运重建的临床方法中可能导致不利结果的几个缺点。因此，我们的审查审查在临床条件下遇到的挑战，并总结了目前的研究结果，试图从基础研究过渡到临床实践提供方向。
Regenerative endodontic procedures for immature permanent teeth with apical periodontitis confer biological advantages such as tooth homeostasis, enhanced immune defense system, and a functional pulp-dentin complex, in addition to clinical advantages such as the facilitation of root development. Currently, this procedure is recognized as a paradigm shift from restoration using materials to regenerate pulp-dentin tissues. Many studies have been conducted with regard to stem/progenitor cells, scaffolds, and biomolecules, associated with pulp tissue engineering. However, preclinical and clinical studies have evidently revealed several drawbacks in the current clinical approach to revascularization that may lead to unfavorable outcomes. Therefore, our review examines the challenges encountered under clinical conditions and summarizes current research findings in an attempt to provide direction for transition from basic research to clinical practice.