The diuretic response to administered water in patients with primary myxedema.
The diuretic response to administered water in patients with primary myxedema.
复制标题
原发性粘液性水肿患者对饮水的利尿反应。
DOI：
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发表时间：
1960
影响因子：
5.8
通讯作者：
S. Papper
中科院分区：
文献类型：
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作者：
K. Bleifer;J. Belsky;L. Saxon;S. Papper
研究了8例典型的未经治疗的原发性黏液性水肿患者对水的利尿反应。8例患者中有2例的最大尿流率明显低于正常范围（最小，约为每分钟8毫升）。在甲状腺干燥治疗后重新研究的5例患者中，包括治疗前尿流量峰值大于8ml / min的3例，最大利尿反应增加。其中4例患者治疗后最大尿流量期尿液比治疗前更稀。总溶质或钠排泄率与尿流量增加没有一致的关系。5例患者治疗后内源性肌酐清除率均显著升高。原发性黏液性水肿中水利尿的适度限制可能归因于肾小球滤过率的降低。对水的利尿反应是鉴别原发性黏液性水肿的有效试验。
ABSTRACT The diuretic response to administered water was studied in 8 patients with typical, untreated primary myxedema. The maximal rate of urine flow was definitely reduced below the normal range (minimum, approximately 8 ml. per minute) in 2 of the 8 patients. In each of 5 patients re-studied following treatment with desiccated thyroid, including 3 whose pre-treatment peak flow of urine was greater than 8 ml. per minute, there was an increase in maximal diuretic response. The urine during periods of maximal flow after treatment was more dilute than before treatment in 4 of these patients. The rate of total solute or sodium excretion did not bear a consistent relationship to increased urine flow. Endogenous creatinine clearance increased significantly after treatment in all 5 patients. The modest limitation in water diuresis observed in primary myxedema may be attributed to a reduction in glomerular filtration rate. That the diuretic response to water is a useful test to differentiate primary myxedema f...