Directed Axonal Outgrowth Using a Propagating Gradient of IGF-1
Directed Axonal Outgrowth Using a Propagating Gradient of IGF-1
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DOI：
10.1002/adma.201305995
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发表时间：
2014-08-06
影响因子：
29.4
通讯作者：
Park, Jon
中科院分区：
文献类型：
--
作者：
Lee, Wonjae;Frank, Curtis W.;Park, Jon
轴突生长的时空调节有助于指导神经损伤或疾病中神经元的从头连接或重新连接。在这里，我们成功地构建了一种生物相容的引导装置，其中IGF-1梯度的线性传播顺序地引导轴突生长。我们观察到广泛的体外轴突延伸超过5毫米，所需的生长速度类似于1毫米/天。
The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivity or reconnectivity of neurons in neurological injury or disease. Here we report the successful construction of a biocompatible guidance device, in which a linear propagation of IGF-1 gradient sequentially directs axon outgrowth. We observe the extensive in vitro axonal extension over 5 mm with a desired growth rate of similar to 1 mm/day.