The presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density
The presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density
复制标题
DOI：
10.1590/s0004-28032007000300016
复制
发表时间：
2007-09-01
影响因子：
--
通讯作者：
Barbosa, Alfredo J. A.
中科院分区：
文献类型：
--
作者：
Kakehasi, Adriana M.;Mendes, Cláudia M. C.;Barbosa, Alfredo J. A.
背景 - 骨质疏松症影响大约 30% 的绝经后妇女。胃切除术、恶性贫血以及最近的幽门螺杆菌感染都与骨质疏松症的发病机制有关。壁细胞量减少是这些情况的共同特征。目的 - 研究绝经后妇女慢性胃炎、泌酸粘膜壁细胞密度和骨矿物质密度之间的可能关系，因为慢性胃炎、幽门螺杆菌感染和骨质疏松症在老年人中常见。方法 - 对 50 名绝经后妇女（61.77 岁）进行胃十二指肠内窥镜检查和双能 X 射线骨密度测定。通过测定壁细胞密度来客观评估腺体萎缩。通过组织学、尿素酶试验和C-13呼气试验评价幽门螺杆菌感染。结果 - 32 名患者（64%）出现慢性多灶性胃炎，其中 20 名患者（40%）出现胃粘膜萎缩迹象。 18 名患者（36%）发现腰椎骨质疏松症。患有和不患有骨质疏松症的患者的壁细胞密度分别为948 +/- 188 和804 +/- 203 细胞/mm(2)。 10名骨质疏松症患者（55%）和24名非骨质疏松症患者（75%）感染幽门螺杆菌。结论 - 与未患骨质疏松症的女性相比，患有骨质疏松症的绝经后女性的壁细胞密度保存完好。两组之间的幽门螺杆菌感染情况没有差异。我们的结论是，萎缩性慢性胃炎和幽门螺杆菌似乎都不是绝经后妇女骨质疏松症的可靠危险因素。
Background - Osteoporosis affects approximately 30% of postmenopausal women. Gastrectomy, pernicious anemia, and more recently Helicobacter pylori infection, have all been implicated in the pathogenesis of osteoporosis. A reduced parietal cell mass is a common feature in these conditions. Aim - To study a possible relationship between chronic gastritis, parietal cell density of the oxyntic mucosa and bone mineral density in postmenopausal women, as chronic gastritis, Helicobacter pylori infection and osteoporosis are frequently observed in the elderly. Methods - Fifty postmenopausal women (61.77 years) were submitted to gastroduodenal endoscopy and bone densitometry by dual energy X-ray absorptiometry. Glandular atrophy was evaluated objectively by the determination of parietal cell density. Helicobacter pylori infection was evaluated by histology, urease test and breath test with C-13. Results - Thirty-two patients (64%) presented chronic multifocal gastritis, and 20 of them (40%) showed signs of gastric mucosa atrophy. Lumbar spine osteoporosis was found in 18 patients (36%). The parietal cell density in patients with and without osteoporosis was 948 +/- 188 and 804 +/- 203 cells/mm(2), respectively. Ten osteoporotic patients (55%) and 24 non-osteoporotic patients (75%) were infected by Helicobacter pylori. Conclusion - Postmenopausal women with osteoporosis presented a well-preserved parietal cell density in comparison with their counterparts without osteoporosis. Helicobacter pylori infection was not different between the two groups. We concluded that neither atrophic chronic gastritis nor Helicobacter pylori seem to be a reliable risk factor to osteoporosis in postmenopausal women.