Cognitive training for persons with mild cognitive impairment
Cognitive training for persons with mild cognitive impairment
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DOI：
10.1017/s104161020700631x
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发表时间：
2008-02-01
影响因子：
7
通讯作者：
Belleville, Sylvie
中科院分区：
文献类型：
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作者：
Belleville, Sylvie
最近的随机对照试验和实验研究的荟萃分析表明，非药物认知训练对健康老年人的认知功能有积极影响。此外，一项针对老年人的大规模随机对照试验表明，在五年的随访中，训练延迟了他们的认知和功能下降。这支持认知训练作为延迟轻度认知障碍（MCI）患者认知下降的潜在有效方法。大多数关于认知训练对MCI影响的研究都报告说，训练后对记忆客观指标的表现有所提高，而少数人报告说，训练对客观认知指标没有影响。有趣的是，一些报告认知训练对MCI患者有积极影响的研究观察到了大到中等的效应量。然而，所有这些研究都具有有限的功效，并且很少使用长期随访或功能影响措施。总体而言，这篇综述强调了需要一个对照良好的随机试验来评估认知训练在MCI中的疗效。它还提出了一些悬而未决的问题，包括适当的结果措施，泛化和干预形式的选择问题。
Recent randomized control trials and meta-analyses of experimental studies indicate positive effects of non-pharmacological cognitive training on the cognitive function of healthy older adults. Furthermore, a large-scale randomized control trial with older adults, independent at entry, indicated that training delayed their cognitive and functional decline over a five-year follow-up. This supports cognitive training as a potentially efficient method to postpone cognitive decline in persons with mild cognitive impairment (MCI). Most of the research on the effect of cognitive training in MCI has reported increased performance following training on objective measures of memory whereas a minority reported no effect of training on objective cognitive measures. Interestingly, some of the studies that reported a positive effect of cognitive training in persons with MCI have observed large to moderate effect size. However, all of these studies have limited power and few have used long-term follow-ups or functional impact measures. Overall, this review highlights a need for a well-controlled randomized trial to assess the efficacy of cognitive training in MCI. It also raises a number of unresolved issues including proper outcome measures, issues of generalization and choice of intervention format.