SENSITIVITY CHANGES TO DOPAMINERGIC AGENTS IN FINE MOTOR CONTROL OF RHESUS-MONKEYS AFTER REPEATED METHAMPHETAMINE ADMINISTRATION
SENSITIVITY CHANGES TO DOPAMINERGIC AGENTS IN FINE MOTOR CONTROL OF RHESUS-MONKEYS AFTER REPEATED METHAMPHETAMINE ADMINISTRATION
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DOI：
10.1016/0091-3057(85)90522-2
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发表时间：
1985-01-01
影响因子：
3.6
通讯作者：
SCHUSTER, CR
中科院分区：
文献类型：
--
作者：
ANDO, K;JOHANSON, CE;SCHUSTER, CR
长期的行为和神经化学作用的重复甲基苯丙胺（MA）管理进行了调查，在恒河猴训练，以执行精细运动任务，需要控制施加的力量在指定的时间。训练恒河猴将其手臂伸入管中，以25-40 g的力按压杠杆5 s，以接收1.5 ml水。i.m.的影响。比较MA、阿朴吗啡（APO）和氟哌啶醇（HAL）重复给药前和给药后2周的反应。在此期间，MA分4次给药，从每日总剂量4 mg/kg/天开始，逐渐增加至40 mg/kg/天。当从1个月开始重新测定剂量-反应函数时，观察到对MA的耐受性、对HAL的敏感性增加以及对APO的敏感性无一致变化。在重复MA给药后。在这些测定完成后一个月，分析了猴子大脑中单胺的变化。尾状核中的多巴胺和额叶皮质中的5-羟色胺显著减少。运动成绩对药物敏感性的改变与多巴胺耗竭有关。
Long-term behavioral and neurochemical effects of repeated methamphetamine (MA) administration were investigated in rhesus monkeys trained to perform a fine motor task requiring control of exerted force for a specified time. Rhesus monkeys were trained to extend their arms into a tube to press a lever with a force between 25-40 g for 5 s, in order to receive 1.5 ml of water. The effects of i.m. administration of MA, apomorphine (APO) and haloperidol (HAL) on responding were compared before and after a 2-wk period of repeated MA administration. During this period, MA was given in 4 divided doses starting at a total daily dose of 4 mg/kg per day and increasing to 40 mg/kg per day. Tolerance to MA, increased sensitivity to HAL and no consistent sensitivity change to APO were observed when dose-response functions were redetermined starting 1 mo. after the repeated MA administration. One month after these determinations were completed, the brains of the monkeys were analyzed for changes in monoamines. Significant depletions of dopamine in the caudate nucleus and of serotonin in the frontal cortex were seen. The sensitivity changes to the drugs on performance were apparently related to the dopamine depletion.