CASPASE EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA
CASPASE EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA
复制标题
DOI：
10.1002/hed.21602
复制
发表时间：
2011-08-01
影响因子：
2.9
通讯作者：
Soares, Fernando Augusto
中科院分区：
文献类型：
--
作者：
Coutinho-Camillo, Claudia Malheiros;Lourenco, Silvia Vanessa;Soares, Fernando Augusto
背景。细胞凋亡是一种基因程序化的细胞死亡形式，半胱天冬酶是其中的核心成分。通过组织芯片技术，我们分析了229例口腔鳞状细胞癌（OSCC）中caspases 3、6、7、8、9和10的免疫表达。我们检查的所有蛋白都在原发性OSCC样品中表达。Caspases 8、9显著表达，Caspases 3、6、7、10偶有表达。caspase 7高表达和低表达患者的无病生存率存在显著差异，我们的多因素分析提示caspase 7的表达是oscc患者的独立预后因素。本研究提示caspase调控OSCC的发生，caspase 7的表达是OSCC局部复发的预测因子。(C) 2010 Wiley期刊公司中国生物医学工程学报（英文版），2011
Background. Apoptosis is a genetically programmed form of cell death, of which caspases are the central components.Methods. By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10.Results. All proteins that we examined were expressed in primary OSCC samples. Caspases 8 and 9 were prominently expressed, and caspases 3, 6, 7, and 10 were occasionally expressed. Disease-free survival differed significantly between caspase 7 high-expressing and low-expressing patients, and our multivariate analysis suggested that expression of caspase 7 is an independent prognostic factor for patients with OSCC.Conclusion. This study suggests that caspases regulate the tumorigenesis of OSCC and that caspase 7 expression is a predictor of locoregional recurrence of OSCC. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1191-1198, 2011