Lithium-sensitive production of inositol phosphates during amphibian embryonic mesoderm induction.
Lithium-sensitive production of inositol phosphates during amphibian embryonic mesoderm induction.
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两栖动物胚胎中胚层诱导过程中肌醇磷酸盐的锂敏感生产。
DOI：
10.1126/science.1314424
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Busa,WB
中科院分区：
文献类型：
--
作者：
Maslanski,JA;Leshko,L;Busa,WB
中胚层的诱导和体轴的确定被认为涉及生长因子介导的细胞-细胞信号传导，但信号转导途径尚不清楚。Li+在许多细胞中抑制多磷酸肌苷（PI）周期信号转导通路，也破坏轴的确定和中胚层诱导。PI周期衍生的第二信使肌醇1,4,5-三磷酸在正常胚胎中胚层诱导过程中含量增加；Li+的添加抑制了胚胎肌醇单磷酸酶，并逆转了这种增加。因此，胚胎PI周期活性的特征表明它可能在中胚层诱导和轴决定中起作用。
Mesoderm induction and body axis determination in frog (Xenopus) embryos are thought to involve growth factor-mediated cell-cell signaling, but the signal transduction pathways are unknown. Li+, which inhibits the polyphosphoinositide (PI) cycle signal transduction pathway in many cells, also disrupts axis determination and mesoderm induction. Amounts of the PI cycle-derived second messenger, inositol 1,4,5-trisphosphate, increased during mesoderm induction in normal embryos; addition of Li+inhibited the embryonic inositol monophosphatase and reversed this increase. Embryonic PI cycle activity thus shows characteristics that indicate it may function in mesoderm induction and axis determination.