Quantitative Spectroscopic Imaging with In Situ Measurements of Tissue Water T1, T2, and Density
Quantitative Spectroscopic Imaging with In Situ Measurements of Tissue Water T1, T2, and Density
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DOI：
10.1002/mrm.22060
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发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Shah, N. J.
中科院分区：
文献类型：
--
作者：
Gasparovic, C.;Neeb, H.;Shah, N. J.
The use of tissue water as a concentration standard in proton magnetic resonance spectroscopy (H-1-MRS) of the brain requires that the water proton signal be adjusted for relaxation and partial volume effects. While single voxel H-1-MRS studies have often included measurements of water proton T-1, T-2, and density based on additional H-1-MRS acquisitions (e.g., at multiple echo or repetition times), this approach is not practical for H-1-MRS imaging (H-1-MRSI). In this report we demonstrate a method for using in situ measurements of water T-1, T-2, and density to calculate metabolite concentrations from H-1-MRSI data. The relaxation and density data are coregistered with the H-1-MRSI data and provide detailed information on the water signal appropriate to the individual subject and tissue region. We present data from both healthy subjects and a subject with brain lesions, underscoring the importance of water parameter measurements on a subject-by-subject and voxel-by-voxel basis. Magn Reson Med 62:583-590, 2009. (C) 2009 Wiley-Liss, Inc.
