Cytokine, sickness behavior, and depression
Cytokine, sickness behavior, and depression
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DOI：
10.1016/j.ncl.2006.03.003
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发表时间：
2006-08-01
影响因子：
2.4
通讯作者：
Dantzer, Robert
中科院分区：
文献类型：
--
作者：
Dantzer, Robert
疾病行为是宿主对感染事件的适应性重组。这个过程是由促炎细胞因子触发的，这些细胞因子是响应于特定的病原体相关分子模式而产生的。外周产生的细胞因子通过快速神经通路和较慢的体液通路间接作用于大脑。这两种途径联合收割机在大脑中的巨噬细胞样细胞和小胶质细胞中产生促炎细胞因子。在慢性炎症性疾病期间，脑细胞因子系统也可以被外源性细胞因子或内源性细胞因子激活。大脑细胞因子系统的不受控制的激活导致抑郁症特征的认知和情绪改变。
Sickness behavior is the adaptive reorganization of the priorities of the host in response to an infectious episode. This process is triggered by proinflammatory cytokines that are produced in response to specific pathogen-associated molecular patterns. Peripherally produced cytokines act indirectly on the brain via a fast neural pathway and a slower humoral pathway. These two pathways combine to produce proinflammatory cytokines in macrophage-like cells and microglia in the brain. The brain cytokine system also can be activated by exogenous cytokines or endogenous cytokines during chronic inflammatory disease. Uncontrolled activation of the brain cytokine system leads to cognitive and mood alterations characteristic of depression.