Hemispheric specialization for language:: Brain volume matters
Hemispheric specialization for language:: Brain volume matters
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DOI：
10.1016/j.brainres.2005.11.037
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发表时间：
2006-01-12
期刊：
影响因子：
2.9
通讯作者：
Tzourio-Mazoyer, N
中科院分区：
文献类型：
--
作者：
Josse, G;Hervé, PY;Tzourio-Mazoyer, N
增加脑容量可能会通过更长的信息传输延迟对支持语言的分布式网络施加限制。在这里，我们评估了在语言理解和语言产生任务期间，通过 PET 探测，脑容量和其他假定的 Perisylvian 语言区域功能变异性预测因素的相对影响。就语言理解（听故事）而言，颞平面、脑容量和惯用手的线性组合可以解释在侧裂周围区域观察到的近 60% 的功能不对称。没有脑容量，拟合优度显着下降（39%，P < 0.05），而且不再检测到惯用手的影响。这是因为在我们的样本中，左撇子 (n = 12) 的大脑体积明显大于右撇子 (n = 8，P = 0.03)。至于语言产生（动词生成），脑容量和颞平面也发挥了作用。然而，在这种情况下，功能变异的主要预测因素是利手习惯，右手习惯程度越高，左下额叶区域的激活程度越高。根据感兴趣的语言成分，这些结果支持关于半球专业化的不同（但兼容）理论。理解的左特化可以归因于处理语音刺激的限制，而语言的手势起源主要由我们观察到的生产的左特化和右手习惯之间的关系支持。 (c) 2005 Elsevier B.V. 保留所有权利。
Increasing brain volume may impose constraints, through longer information transfer delays, on the distributed networks supporting language. Here, we assessed the relative effects of brain volume and other putative predictors of the functional variability of perisylvian language areas, as probed with PET, during both a language comprehension and a language production task. In the case of language comprehension (story listening), a linear combination of planum temporale surface, brain volume and handedness could explain almost 60% of the functional asymmetry observed in the perisylvian area. Without brain volume, the goodness of fit was significantly decreased (39%, P < 0.05), and furthermore, the effect of handedness was not detected anymore. This was due to the fact that in our sample, left-handers (n = 12) had a significantly larger brain volume as compared to right-handers (n = 8, P = 0.03). As for language production (verb generation), brain volume and the planum temporale also played a role. However, in this case, the main predictor of functional variability was handedness, where a greater degree of right-handedness was associated with larger activation of left inferior frontal regions. Depending on the language component of interest, these results support different (yet compatible) theories on hemispheric specialization. Left specialization for comprehension could be attributed to the constraints of processing speech stimuli, while a gestural origin of language is mostly supported by the relation we observed between left specialization for production and right-handedness. (c) 2005 Elsevier B.V. All rights reserved.