Complex systems analysis: A tool for shock research
Complex systems analysis: A tool for shock research
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DOI：
10.1097/00024382-200116040-00002
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发表时间：
2001-10-01
期刊：
影响因子：
3.1
通讯作者：
Kepler, TB
中科院分区：
文献类型：
--
作者：
Buchman, TG;Cobb, JP;Kepler, TB
在过去的一个世纪里，研究休克的学生一直致力于阐明导致循环衰竭的具体机制，或者作为循环衰竭的结果而失败。尽管旨在支持或恢复单个器官系统的临床策略已被证明是有效的，但许多患者死于更广泛的多器官系统衰竭。我们认为，一般生物系统的失败不能通过依赖还原论科学来解释。我们提出复杂系统分析是休克研究的重要工具，并评估其在基因组技术中的应用。
For the past century, students of shock have focused research efforts to illuminate specific mechanisms that cause, or fail as a consequence of, circulatory collapse. Although clinical strategies aimed at supporting or restoring individual organ systems have proven effective, many patients succumb to more generalized multiple organ system failure. We suggest that general biological systems failure cannot be interpreted through reliance on reductionist science. We propose that complex systems analysis is an essential tool for shock research and we evaluate its application to genomic technologies.