The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice.
The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice.
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儿科实践中细支气管炎的病因学和流行病学谱。
DOI：
10.1016/s0022-3476(79)80647-2
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
R. M. Christian
中科院分区：
文献类型：
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作者：
F. Henderson;W. A. Clyde;A. Collier;F. W. Denny;R. Senior;C. Sheaffer;William Conley;R. M. Christian
为了广泛了解喘息相关呼吸道感染的原因和发生模式，我们分析了儿科实践中一项为期11年的急性下呼吸道疾病研究的数据。尽管半数WARI发生在2岁以下的儿童中，但在9岁以上患有下呼吸道疾病的儿童中仍观察到19%的喘息。男性经历LRI的频率是女性的1.25倍;男性WARI的相对风险为1.35。从21%的WARI患者中分离到非细菌性病原体，呼吸道合胞病毒、1型和3型副流感病毒、腺病毒和肺炎支原体占分离株的81%。患者年龄影响这些药物的恢复模式。5岁以下儿童WARI最常见的病因是RSV，而肺炎支原体是学龄儿童喘息性疾病中最常见的分离株。这些数据扩展了我们对WARI病因的理解，对诊断医生和对控制下呼吸道疾病感兴趣的研究人员都很有用。
To develop a broad understanding of the causes and patterns of occurrence of wheezing associated respiratory infections, we analyzed data from an 11-year study of acute lower respiratory illness in a pediatric practice. Although half of the WARI occurred in children less than 2 years of age, wheezing continued to be observed in 19% of children greater than 9 years of age who had lower respiratory illness. Males experienced LRI 1.25 times more often than did females; the relative risk of males for WARI was 1.35. A nonbacterial pathogen was recovered from 21% of patients with WARI; respiratory syncytial virus, parainfluenza virus types 1 and 3, adenoviruses, andMycoplasma pneumoniaeaccounted for 81% of the isolates. Patient age influenced the pattern of recovery of these agents. The most common cause of WARI in children under 5 years of age was RSV whereasMycoplasma pneumoniaewas the most frequent isolate from school age children with wheezing illness. The data expand our understanding of the causes of WARI and are useful to diagnosticians and to researchers interested in the control of lower respiratory disease.