Elevated lipoprotein(a) levels in renal transplantation and hemodialysis patients.
Elevated lipoprotein(a) levels in renal transplantation and hemodialysis patients.
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肾移植和血液透析患者脂蛋白（a）水平升高。
DOI：
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发表时间：
1991
影响因子：
4.2
通讯作者：
A. Dasgupta
中科院分区：
文献类型：
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作者：
P. Heimann;M. Josephson;S. Fellner;J. Thistlethwaite;F. Stuart;A. Dasgupta
高脂血症会给血液透析和肾移植患者带来心血管疾病的风险。尽管两个群体之间的血脂谱不同，但我们评估了两个群体具有相似的脂蛋白(a) [Lp(a)]异常的可能性。血液透析和移植受者的平均血清 Lp(a) 和平均值标准误差 (SEM) 分别为 16.6 +/- 4.7 和 18.3 +/- 3.6 mg/dl，而健康对照者为 10.7 +/- 4.1 mg/dl，p 小于 0.05。透析和肾移植患者的血清 Lp(a) 水平显着升高，这表明两组动脉粥样硬化高发生率至少有一种共同的致病机制。
Hyperlipidemia poses a risk for cardiovascular disease in both hemodialysis and renal transplantation patients. Although lipid profiles differ between the 2 populations, we evaluated the possibility that both groups have similar abnormalities of lipoprotein(a) [Lp(a)]. Mean serum Lp(a) and standard error of the mean (SEM) in hemodialysis and transplant recipients was 16.6 +/- 4.7 and 18.3 +/- 3.6 mg/dl, respectively, compared with 10.7 +/- 4.1 mg/dl in healthy controls, p less than 0.05. That serum Lp(a) levels are significantly elevated in dialysis and renal transplantation patients suggests at least 1 common pathogenic mechanism for the high incidence of atherosclerosis in both groups.