Effects of inhalation anaesthetics on the release of acetylcholine in the rat cerebral cortex in vivo
Effects of inhalation anaesthetics on the release of acetylcholine in the rat cerebral cortex in vivo
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DOI：
10.1093/bja/80.3.365
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发表时间：
1998-03-01
影响因子：
9.8
通讯作者：
Mori, K
中科院分区：
文献类型：
--
作者：
Shichino, T;Murakawa, M;Mori, K
通过分析脑电图、网状多单位活动和行为变化，我们将全身麻醉药分为三类：中枢神经系统（CNS）抑制剂、中枢神经系统兴奋剂和致癫痫剂。中枢神经系统神经活动的变化与递质释放的改变有关。我们试图通过脑微透析阐明广泛使用的吸入麻醉剂，例如异氟烷（中枢神经系统抑制剂）、一氧化二氮（中枢神经系统兴奋剂）和七氟烷（致癫痫剂）对大脑皮层乙酰胆碱（ACh）释放的作用。异氟醚和七氟醚以剂量相关的方式抑制乙酰胆碱的释放，但在洗脱后恢复。在相同的 MAC 值下，七氟醚和异氟醚的效果没有显着差异。相比之下，一氧化二氮显着增强乙酰胆碱的释放。这些发现表明，皮质胆碱能细胞对不同麻醉剂的反应反映了它们的神经生理学特征，即它们是否刺激或抑制中枢神经系统神经元。
By analysing the EEG, reticular multi-unit activity and behavioural changes, we have classified general anaesthetics into three groups: central nervous system (CNS) depressant, CNS excitant and epileptogenic agents. Changes in CNS neural activity are associated with alteration in transmitter release. We have attempted to clarify the actions of widely used inhalation anaesthetics, such as isoflurane (CNS depressant), nitrous oxide (CNS excitant) and sevoflurane (epileptogenic) on acetylcholine (ACh) release in the cerebral cortex using brain microdialysis. ACh release was suppressed by isoflurane and sevoflurane in a dose-related manner but recovered on wash-out. There were no significant differences between the effects of sevoflurane and isoflurane at the same MAC values. In contrast, ACh release was enhanced significantly by nitrous oxide. These findings indicate that the response of the cortical cholinergic cells to different anaesthetics reflects their neurophysiological characteristics, that is whether they stimulate or suppress CNS neurones.