Gastrointestinal motor effects of erythromycin in humans.
Gastrointestinal motor effects of erythromycin in humans.
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DOI：
10.1016/0016-5085(91)90383-v
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发表时间：
1991-12
期刊：
影响因子：
29.4
通讯作者：
S. Sarna;S. Sarna;K. Soergel;K. Soergel;T. Koch;T. Koch;J. E. Stone;J. E. Stone;C. M. Wood;C. M. Wood;R. P. Ryan;R. P. Ryan;R. Arndorfer;R. Arndorfer;J. Cavanaugh;J. Cavanaugh;H. Nellans;H. Nellans;Martha B. Lee;Martha B. Lee
中科院分区：
文献类型：
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作者：
S. Sarna;S. Sarna;K. Soergel;K. Soergel;T. Koch;T. Koch;J. E. Stone;J. E. Stone;C. M. Wood;C. M. Wood;R. P. Ryan;R. P. Ryan;R. Arndorfer;R. Arndorfer;J. Cavanaugh;J. Cavanaugh;H. Nellans;H. Nellans;Martha B. Lee;Martha B. Lee
本文研究了8名健康志愿者在空腹和进食状态下静脉注射有效抗菌剂红霉素对胃肠运动的影响。运动活动由多腔测压管记录。通过计算机方法对数据进行可视化分析。采集血样进行红霉素和胃动素检测。在胃窦，红霉素在禁食状态下给药后0~60min的总收缩时程、收缩幅度、收缩下面积和0~30min的收缩频率均显著增加。在给药状态下，类似的反应大多发生在开始输注红霉素后的0到30分钟。相反，红霉素在进食状态下抑制小肠收缩的频率和缩短持续时间，但在禁食状态下没有影响。胃运动反应与血浆红霉素浓度有关，与血浆胃动素无关。红霉素显著缩短了进食引起的移行性运动复合体紊乱的持续时间。红霉素还会引起上腹部疼痛、腹胀和恶心的症状。无论是禁食状态还是进食状态，腹痛都与胃窦强烈收缩有关；只有在进食状态下才会出现腹胀。恶心在禁食和进食状态下都会发生，但与任何特定的运动活动模式无关。提示红霉素引起的强烈胃窦收缩可加快胃排空速度，但也可能是引起上腹痛和腹胀的原因之一。与禁食状态相比，进食时对红霉素的运动反应较小。红霉素引起的强烈胃窦收缩不是由胃动素的释放介导的。
The effects of an antibacterially effective IV dose of erythromycin on gastrointestinal motor activity were investigated in eight normal healthy human volunteers in the fasted state and the fed state. Motor activity was recorded by a multilumen manometric tube. Data were analyzed visually and by a computer method. Blood samples were obtained for erythromycin and motilin assays. In the gastric antrum, erythromycin significantly increased the total duration, amplitude, and area under contractions from 0 to 60 minutes and frequency of contractions from 0 to 30 minutes from the start of its infusion in the fasted state. A similar response in the fed state occurred mostly from 0 to 30 minutes after the start of erythromycin infusion. By contrast, erythromycin inhibited the frequency and decreased the duration of small intestinal contractions in the fed state but had no effect in the fasted state. The gastric motor response was related to the plasma concentration of erythromycin, but not to plasma motilin. Erythromycin significantly shortened the duration of migrating motor complex disruption by a meal. Erythromycin also induced symptoms of upper abdominal pain, bloating, and nausea. Abdominal pain was related to strong antral contractions in both fasted and fed states; bloating occurred only in the fed state. Nausea occurred in both fasted and fed states, but it was not related to any specific pattern of motor activity. It is concluded that the strong antral contractions induced by erythromycin may accelerate the rate of gastric emptying, but they may also be responsible for causing the sensations of upper abdominal pain and bloating. The motor response to erythromycin is less during the fed than during the fasted state. The strong antral contractions induced by erythromycin are not mediated by the release of motilin.