ANTIFUNGAL ACTIVITIES OF HOP BITTER RESINS AND RELATED-COMPOUNDS
ANTIFUNGAL ACTIVITIES OF HOP BITTER RESINS AND RELATED-COMPOUNDS
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DOI：
10.1080/00021369.1985.10866749
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
SATO, Y
中科院分区：
文献类型：
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作者：
MIZOBUCHI, S;SATO, Y
蛇麻酮、蛇麻酮及其相关化合物具有抗真菌活性。对这些化合物进行活性测试，以确定它们的结构-活性关系。结果表明，六元环化合物对毛癣菌属真菌具有一定的抗真菌活性; 5元化合物无活性。在所测试的化合物中，3-异戊烯基间苯异戊酮显示出最高的活性，几乎与灰黄霉素对毛癣菌属的活性相同。它还对念珠菌属、镰刀菌属、毛霉属和葡萄球菌属具有有效活性。结果表明，其活性受其酰基结构的影响。
Humulone, lupulone and related compounds were found to have antifungal activities. The activities of these compounds were tested to determine their structure-activity relationships. As a result, it was found that the 6-membered compounds had antifungal activities against Trichophyton spp.; the 5-membered compounds were inactive. Among the compounds tested, 3-isopentenylphlorisovalerophenone showed the highest activity, being almost the same as griseofulvin against Trichophyton spp. It also had potent activity against Candida, Fusarium, Mucor and Staphylococcus spp. It is suggested that its activity was significantly affected by the structure of its acyl group.