AGGRESSIVE-BEHAVIOR INDUCES RELEASE OF NERVE GROWTH-FACTOR FROM MOUSE SALIVARY-GLAND INTO THE BLOOD-STREAM
AGGRESSIVE-BEHAVIOR INDUCES RELEASE OF NERVE GROWTH-FACTOR FROM MOUSE SALIVARY-GLAND INTO THE BLOOD-STREAM
复制标题
DOI：
10.1073/pnas.83.16.6184
复制
发表时间：
1986-08-01
影响因子：
11.1
通讯作者：
LEVIMONTALCINI, R
中科院分区：
文献类型：
--
作者：
ALOE, L;ALLEVA, E;LEVIMONTALCINI, R
由6-8周的社会隔离引起的种内争斗导致神经生长因子（NGF）大量释放到成年雄性小鼠的血液中。循环中的神经生长因子的量与打斗的次数高度相关。生物学、放射免疫学、免疫组织化学和超微结构研究表明，NGF在战斗后几分钟内从唾液腺分泌到血液中，并在3-4小时后达到最高水平。肾上腺素能神经支配的唾液腺或肾上腺切除术不取消神经生长因子的释放。促皮质激素不诱导血液中的NGF增加。每日给予高度纯化的NGF（3 μ g/g体重）导致肾上腺体积的显著增加。这些发现是明确的证据，小鼠唾液腺的生理作用，作为血液神经生长因子的主要来源。
Intraspecific fighting induced by 6-8 weeks of social isolation results in massive release of nerve growth factor (NGF) into the bloodstream of adult male mice. The amount of circulating NGF is highly correlated with the number of fighting episodes. Biological, radioimmunological, immunohistochemical, and ultrastructural studies show that NGF is discharged from the salivary gland into the blood within minutes after fighting and reaches the highest level 3-4 hr later. Adrenergic innervation of the salivary gland or adrenalectomy does not abolish the NGF release. Corticotropic hormones do not induce NGF increase in the blood. Daily administrations of highly purified NGF (3 .mu.g per g of body weight) result in a considerable increase in the volume of adrenal glands. These findings are unequivocable evidence for a physiological role of the mouse salivary glands as a major source of blood NGF.