SLOW SPIKE-WAVE ACTIVITY IN EEG AND ASSOCIATED CLINICAL FEATURES - OFTEN CALLED LENNOX OR LENNOX-GASTAUT SYNDROME
SLOW SPIKE-WAVE ACTIVITY IN EEG AND ASSOCIATED CLINICAL FEATURES - OFTEN CALLED LENNOX OR LENNOX-GASTAUT SYNDROME
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DOI：
10.1212/wnl.27.8.746
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发表时间：
1977-01-01
期刊：
影响因子：
9.9
通讯作者：
MARKLAND, ON
中科院分区：
文献类型：
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作者：
MARKLAND, ON
本文对83例脑电慢棘波活动患者的临床特点进行了研究。82例患者出现了通常难以治愈的癫痫发作。大多数患者在出生后2年内出现癫痫发作。轻度运动性惊厥单独发作或合并其他类型惊厥的发生率为80%，且多数有一种以上的惊厥类型。强直-阵挛发作、小运动性惊厥和失神发作是最常见的，发生率为37%。66例患者明确发育迟缓，49例患者有明确的运动障碍。在53例患者中确定了导致脑损伤的病因。系列脑电研究表明，低位节律、独立的多灶性棘波放电和慢棘波活动的脑电模式之间存在密切关系。Lennox-Gastaut综合征适用于脑电波活动缓慢、表现出智力低下和有各种类型难治性癫痫发作的患者。该综合征并不意味着一种病理实体，因为许多不同的过程，无论是静态的还是进行性的，都可以产生这种综合征。
Clinical features were studied in 83 patients with slow spike-wave activity in the EEG. Epileptic seizures, usually intractable, occurred in 82 patients. The majority had the onset of seizures during the first 2 yr of life. Minor motor seizures alone or in combination with other types of seizures occurred in 80%, and most had more than 1 type of seizure. The combination of tonic-clonic, minor motor and absence seizures was the commonest, occurring in 37%. Patients (66) were definitely retarded and 49 showed definite motor impairment. Etiologic factors responsible for cerebral insult were identified in 53 patients. Serial EEG studies showed a close relationship between the EEG patterns of hypsarrhythmia, independent multifocal spike discharges and slow spike-wave activity. The eponym Lennox-Gastaut syndrome is appropriate for a patient who has slow spike-wave activity in the EEG, exhibits mental retardation and has intractable seizures of various types. The syndrome does not imply a pathologic entity because many diverse processes, both static and progressive, can produce this syndrome.