Circulating S100B is increased after bilateral femur fracture without brain injury in the rat
Circulating S100B is increased after bilateral femur fracture without brain injury in the rat
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DOI：
10.1093/bja/aeg225
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发表时间：
2003-10-01
影响因子：
9.8
通讯作者：
Bahrami, S
中科院分区：
文献类型：
--
作者：
Pelinka, LE;Szalay, L;Bahrami, S
Background. S100B is an acknowledged marker of brain damage. However, trauma without brain damage also causes an increase in S100B. S100B concentrations are highest in multiple trauma patients with long bone fractures. Clinically, extensive long bone fractures are associated with haemorrhagic shock and haemorrhagic shock per se is associated with increased S100B. The aim of our experimental study was to verify the S100B increase in long bone fracture without haemorrhagic shock.Methods and results. Bilateral femur fracture was carried out in 10 anaesthetized rats. Blood samples were drawn for immuno-luminometrical S100B measurement 5, 15, 30, 120, and 240 min after fracture. Mean arterial pressure (MAP), heart rate, and body temperature were monitored continuously. S100B increased after bilateral femur fracture and reached a peak 30-120 min after fracture (P
