Diastereo- and Enantioselective Direct Aldol Reactions in Aqueous Medium: A New Highly Efficient Proline-Sugar Chimeric Catalyst
Diastereo- and Enantioselective Direct Aldol Reactions in Aqueous Medium: A New Highly Efficient Proline-Sugar Chimeric Catalyst
复制标题
DOI：
10.1002/adsc.201100143
复制
发表时间：
2011-06
影响因子：
5.4
通讯作者：
Silvana Pedatella;M. Nisco;D. Mastroianni;D. Naviglio;Ada Nucci;R. Caputo
中科院分区：
文献类型：
--
作者：
Silvana Pedatella;M. Nisco;D. Mastroianni;D. Naviglio;Ada Nucci;R. Caputo
提出了一种新的合成催化剂，它能像酶一样完成直接醛醇反应。在化学产率和非对映体/对映体比率方面，环己酮催化加成到各种取代的苯甲醛上取得了优异的结果。
A new synthetic catalyst, capable of acting like an enzyme in the accomplishment of direct aldol reactions, is presented. Excellent results, in terms of chemical yields and diastereo-/ enantiomeric ratios, are reported for the catalyzed additions of cyclohexanone to variously substituted benzaldehydes.