Modulations of food-derived substances on intestinal permeability in Caco-2 cell monolayers
Modulations of food-derived substances on intestinal permeability in Caco-2 cell monolayers
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DOI：
10.1271/bbb.67.2297
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发表时间：
2003-10-01
影响因子：
1.6
通讯作者：
Konishi, Y
中科院分区：
文献类型：
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作者：
Konishi, Y
本研究以Caco-2细胞为模型，以荧光黄（LY）为细胞旁途径，荧光黄绿素（FC）为单羧酸转运蛋白介导的途径，罗丹明123（RH）为p-糖蛋白介导的外排途径，研究了300多种食物提取物对肠通透性的影响。随着几种提取物的增加或减少LY渗透，增加FC或RH渗透也被观察到，这表明膳食物质在几种肠道吸收途径中的调节。
The effects of more than 300 kinds of food extracts on intestinal permeability were investigated in Caco-2 cells with the use of model compounds: Lucifer Yellow (LY) for the paracellular pathway, Fluorescein (FC) for the monocarboxylic acid transporter-mediated pathway, and Rhodamine 123 (RH) for the p-glycoprotein-mediated efflux pathway. With several extracts of increasing or decreasing LY permeation, increasing FC or RH permeation was also observed, indicating modulation by dietary substances in several pathways for intestinal absorption.