Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae
Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae
复制标题
DOI：
10.1128/aac.46.8.2676-2678.2002
复制
发表时间：
2002-08-01
影响因子：
4.9
通讯作者：
Kundu, M
中科院分区：
文献类型：
--
作者：
Baranwal, S;Dey, K;Kundu, M
喹诺酮类药物是治疗霍乱弧菌引起的霍乱的首选药物之一。在这项研究中，我们证明，除了在靶基因gyrA和parC中检测到的突变外，质子动力依赖性外排还参与了临床分离的霍乱弧菌对喹诺酮类药物的耐药性。
Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae.