Quadriceps strength assessed by magnetic stimulation of femoral nerve in patients with chronic obstructive pulmonary disease
Quadriceps strength assessed by magnetic stimulation of femoral nerve in patients with chronic obstructive pulmonary disease
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股神经磁刺激评估慢性阻塞性肺疾病患者股四头肌力量
DOI：
10.3760/cma.j.issn.0366-6999.2011.15.012
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发表时间：
2011-08-05
影响因子：
6.1
通讯作者：
Chen Rong-chang
中科院分区：
文献类型：
--
作者：
Ju Chun-rong;Chen Rong-chang
背景骨骼肌功能障碍是慢性阻塞性肺疾病（COPD）的重要全身表现之一，与COPD患者的死亡率相关，因此量化其强度具有重要的临床意义和特殊价值。股四头肌最大自主收缩（MVC）通常用于该肌肉力量的常规测量;而股神经磁刺激诱发的抽搐张力（TwQ）已被用于非自主地测量股四头肌力量。本研究旨在探讨COPD患者骨骼肌功能障碍的患病率和严重程度，并探讨一些方法学问题。方法71例COPD患者和60例对照组。股四头肌力量的测量与最大的TwQ和MVC的力量。TwQ和MVC的再现性进行了研究，使用从三个重复maneuvers.Results最大TwQ的场合内的变异性达到了121名参与者在平均90%的刺激器的最大输出。COPD患者TwQ最大值较对照组降低44%~ 47%（P
Background Skeletal muscle dysfunction is one of important systemic manifestations of chronic obstructive pulmonary disease (COPD) and is associated with mortality in patients with COPD, thus quantifying its strength is of great clinical interest and of particular value. Quadriceps maximal volitional contraction (MVC) is often used for the routine measurements of this muscle's strength; while twitch tension (TwQ) evoked by magnetic stimulation of the femoral nerve has been employed for measurement of quadriceps strength non-volitionally. We aimed to investigate the prevalence and severity of skeletal muscle dysfunction in COPD patients by measurement of quadriceps strength with volitional and non-volitional techniques, and to probe into some methodological issues.Methods We recruited 71 COPD patients and 60 control subjects. Quadriceps strength was measured with both maximality of TwQ and MVC force. The reproducibility for TwQ and MVC was investigated using within-occasion variability from three repeated maneuvers.Results Maximal TwQ was achieved in 121 participants at a mean of 90% of the stimulator's maximum output. The mean maxmality of TwQ was decrease by about 44%-47% in COPD patients as compared with controls (P