Cytokine levels in the blood may distinguish suicide attempters from depressed patients
Cytokine levels in the blood may distinguish suicide attempters from depressed patients
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DOI：
10.1016/j.bbi.2010.10.010
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发表时间：
2011-02-01
影响因子：
15.1
通讯作者：
Brundin, Lena
中科院分区：
文献类型：
--
作者：
Janelidze, Shorena;Mattei, Daniele;Brundin, Lena
血浆细胞因子升高是重度抑郁症（MDD）的常见结果，尽管并不一致。目前尚不清楚炎症变化是否仅限于任何特定的抑郁症患者亚组。我们分析了自杀和非自杀抑郁症患者以及健康对照者的三种炎症标志物，并测定了47例自杀未遂者、17例非自杀抑郁症患者和16例健康对照者的血浆白细胞介素（IL）-2，IL-6和肿瘤坏死因子（TNF）-α。采用综合精神病理评定量表（CPRS）和自杀评估量表（SUAS）对研究参与者进行评估，结果发现，与非自杀抑郁症患者和健康对照组相比，自杀抑郁症患者IL-6和TNF-α水平升高，IL-2水平降低。结果进行了调整的细胞因子表达的潜在混杂因素，如年龄，性别，体重指数（BMI），抑郁程度，焦虑，人格障碍，滥用和类型的medication.These结果首次表明，自杀的患者显示出不同的外周血细胞因子谱相比，非自杀抑郁症患者。因此，我们的研究为炎症在自杀的病理生理学中的作用提供了进一步的支持。(C)2010年爱思唯尔公司All rights reserved.
Elevated plasma cytokines is a common finding in Major Depressive Disorder (MDD), although not consistent. It is currently not known whether the inflammatory changes are confined to any specific subgroup of depressive patients. We here analyzed three inflammatory markers in suicidal and non-suicidal depressed patients, as well as healthy controls.Plasma interleukin (IL)-2, IL-6 and tumor necrosis factor (TNF)-alpha were measured in 47 suicide attempters, 17 non-suicidal depressed patients and 16 healthy controls. Study participants were evaluated using the Comprehensive Psychopathological Rating Scale (CPRS) with subscales for anxiety and degree of depression, as well as the Suicide Assessment Scale (SUAS).We found increased levels of IL-6 and TNF-alpha as well as decreased IL-2 concentrations in suicide attempters compared to non-suicidal depressed patients and healthy controls. The results were adjusted for potential confounders of cytokine expression, such as age, sex, body mass index (BMI), degree of depression, anxiety, personality disturbance, abuse and type of medication.These results demonstrate for the first time that suicidal patients display a distinct peripheral blood cytokine profile compared to non-suicidal depressed patients. Thus, our study provides further support for a role of inflammation in the pathophysiology of suicidality. (C) 2010 Elsevier Inc. All rights reserved.