Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis
Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis
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DOI：
10.1212/wnl.0b013e3181aaea32
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发表时间：
2009-07-07
期刊：
影响因子：
9.9
通讯作者：
Cross, A. H.
中科院分区：
文献类型：
--
作者：
Naismith, R. T.;Tutlam, N. T.;Cross, A. H.
目的：确定实用的光学相干断层扫描（OCT），以检测临床和亚临床远程视神经炎（ON），其关系的临床特征ON和视觉功能，以及是否视网膜神经纤维层（RNFL）厚度的功能作为一个替代标记的全球疾病severity.Methods：至少有1个临床ON发作至少6个月前的65名受试者的横断面研究。测量包括临床特征、视力（VA）、对比敏感度（CS）、OCT和视觉诱发电位（VEP）。ON后OCT RNFL的敏感性为60%，随着病情轻和恢复良好而进一步下降。VEP灵敏度为81%（p = 0.002），具有上级。未受影响的眼睛中的亚临床ON存在于32%。VEP识别了75%的亚临床受累眼，OCT识别了
Objectives: Determine the utility of optical coherence tomography (OCT) to detect clinical and subclinical remote optic neuritis (ON), its relationship to clinical characteristics of ON and visual function, and whether the retinal nerve fiber layer (RNFL) thickness functions as a surrogate marker of global disease severity.Methods: Cross-sectional study of 65 subjects with at least 1 clinical ON episode at least 6 months prior. Measures included clinical characteristics, visual acuity (VA), contrast sensitivity (CS), OCT, and visual evoked potentials (VEP).Results: Ninety-six clinically affected optic nerves were studied. The sensitivity of OCT RNFL after ON was 60%, decreasing further with mild onset and good recovery. VEP sensitivity was superior at 81% (p = 0.002). Subclinical ON in the unaffected eye was present in 32%. VEP identified 75% of all subclinically affected eyes, and OCT identified