The craniofacial characteristics of osteogenesis imperfecta patients
The craniofacial characteristics of osteogenesis imperfecta patients
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DOI：
10.1093/ejo/cjl035
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发表时间：
2007-06-01
影响因子：
2.6
通讯作者：
Hsu, Kuang-Hung
中科院分区：
文献类型：
--
作者：
Chang, Pei-Ching;Lin, Shiao-Yu;Hsu, Kuang-Hung
本研究的目的是确定16名成骨不全（OI）患者的颅面特征，10名男性和6名女性，年龄7-15岁。对照组包括863名6至18岁的中国儿童。在侧位X线头影测量片上测量了11个头影测量参考点和25个变量。两组间的差异用科克伦不等方差t检验，62.5%的患者咬合关系为III类。相对于颅底，上颌骨比下颌骨更后缩。面高、有效上下颌长度、前后颅底长度均显著短于对照组。面部分叉，颅底（N-S-Ar，P < 0.001），（Ar-Go-Gn，P < 0.001）角显著增大，关节角结果显示，01例患者的Ⅲ类牙合关系较突出，下颌骨偏侧，面角偏大，面高较矮，与对照组相比，上颌骨和下颌骨的矢状生长缺陷、颅底角变平、颅底生长受损以及下颌骨生长中更多的向前逆时针旋转。
The aim of this study was to identify the craniofacial characteristics of 16 osteogenesis imperfecta (OI) patients, 10 males and 6 females, aged 7-15 years. The control group comprised 863 Chinese children from 6 to 18 years of age. Eleven cephalometric reference points and 25 variables were measured on the lateral cephalometric radiographs. Cochrane's method of unequal variance t-test was used to differentiate the differences between two groups.A Class III occlusal relationship was found in 62.5 per cent of the OI patients. The maxilla was more retrusive than the mandible in relation to the cranial base. Face heights, the effective maxilla and mandibular lengths, and anterior and posterior cranial base lengths were significantly shorter than the control subjects. The facial divergence, the cranial base (N-S-Ar, P < 0.001), and the gonial (Ar-Go-Gn, P < 0.001) angles were significantly enlarged, while the articular angle (S-Ar-Go, P < 0.001) was significantly reduced.The findings showed that the 01 patient had a more prominent Class III occlusal relationship, prognathic mandible, larger facial divergence, shorter face heights, defective sagittal growth of the maxilla and mandible, a flattened cranial base angle, impaired cranial base growth, and more forward counterclockwise rotation in mandibular growth compared with the controls.