Catecholamines are involved in the mechanism of the urinary alcohol level cycle in rats fed ethanol intragastrically at a constant rate
Catecholamines are involved in the mechanism of the urinary alcohol level cycle in rats fed ethanol intragastrically at a constant rate
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DOI：
10.1016/j.lfs.2004.05.032
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发表时间：
2004-11-05
期刊：
影响因子：
6.1
通讯作者：
French, SW
中科院分区：
文献类型：
--
作者：
Li, J;French, BA;French, SW
研究表明，采用早期酒精性肝病大鼠模型，连续灌胃给予乙醇，血液酒精水平存在循环。本研究的目的是确定儿茶酚胺在以恒定速度喂养乙醇时观察到的血液酒精循环的发病机制中所起的作用。在尿酒精水平(UAL)周期的峰值和低谷进行测试，并将结果与对照组进行比较。血儿茶酚素水平在高峰时显著升高，但在低谷时不明显。心得安，一种β肾上腺素能阻滞剂，减弱了周期的幅度。一种名为苯氧基苯扎宁的阿尔法阻滞剂扰乱了这种循环，并将乙醇提高到了致命的水平。结果表明，α和β肾上腺素能机制都是周期发生所必需的。(C)2004 Elsevier Inc.保留所有权利。
Studies have indicated that blood alcohol levels cycle exists when ethanol is fed continuously using the intragastric feeding rat model of early alcoholic liver disease. The aim of the present study was to determine the role played by catecholamines in the pathogenesis of the blood alcohol cycling observed when ethanol is fed at a constant rate. The rats were tested at the peaks and troughs of the urinary alcohol level (UAL) cycle and the results were compared with controls. Blood catecholarnine levels were markedly increased at the peaks, but not at the troughs. Propranolol, a beta adrenergic blocker, attenuated the amplitude of the cycle. Phenoxybenzarnine, an alpha blocker disrupted the cycle and elevated ethanol to fatal levels. The results indicate that both alpha and beta adrenergic mechanisms are required for the cycle to occur. (C) 2004 Elsevier Inc. All rights reserved.