Event-related fMRI evidence of frontotemporal involvement in aberrant response inhibition and task switching in attention-deficit/hlyperactivity disorder
Event-related fMRI evidence of frontotemporal involvement in aberrant response inhibition and task switching in attention-deficit/hlyperactivity disorder
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DOI：
10.1097/01.chi.0000140452.51205.8d
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发表时间：
2004-11-01
影响因子：
13.3
通讯作者：
Reiss, AL
中科院分区：
文献类型：
--
作者：
Tamm, L;Menon, V;Reiss, AL
目的：反应抑制缺陷是注意缺陷多动障碍(ADHD)患者的特征。以前的功能磁共振成像(FMRI)研究这种功能障碍的神经相关性使用了区块设计，这使得很难将特定与反应抑制相关的激活差异与与任务绩效相关的子过程的激活差异分开。目前的研究旨在利用事件相关功能磁共振成像进一步加强我们对ADHD患者这一关键功能的理解。方法：10名被诊断为ADHD的青春期男孩，混合型，以及12名典型的发育正常的对照组，完成一项GO/NOGO任务，该任务被修改为用于新奇加工的对照。结果：注意缺陷多动障碍组的遗漏错误和执行错误明显多于对照组。此外，与对照组相比，ADHD患者在反应抑制期间表现出明显的脑激活异常，包括延伸到辅助运动区的前扣带回/中扣带回的低激活和左侧颞回的过度激活。结论：作者认为额叶区域的激活不足反映了ADHD组在反应/任务转换能力方面的核心缺陷。
Objective: Response inhibition deficits are characteristic of individuals with attention-deficit/hyperactivity disorder (ADHD). Previous functional magnetic resonance imaging (fMRI) studies investigating the neural correlates of this dysfunction have used block designs, making it difficult to disentangle activation differences specifically related to response inhibition from activation differences related to subprocesses involved in task performance. The current study was designed to further enhance our understanding of this critical function in individuals with ADHD using event-related fMRI. Method: Ten adolescent boys diagnosed with ADHD, combined type, and 12 typically developing controls completed a Go/NoGo task modified to control for novelty processing. Results: The ADHD group made significantly more errors of omission and more errors of commission than the control group. Further, compared with controls, individuals with ADHD showed marked abnormalities in brain activation during response inhibition, including hypoactivation of the anterior/mid-cingulate cortex extending to the supplementary motor area and hyperactivation of the left temporal gyrus. Conclusions: The authors suggest that underactivation in frontal regions reflects core deficits in response/task-switching abilities for the ADHD group.