ADRENOCORTICAL-RESPONSE TO NOVELTY STRESS IN RATS WITH DENTATE GYRUS LESIONS
ADRENOCORTICAL-RESPONSE TO NOVELTY STRESS IN RATS WITH DENTATE GYRUS LESIONS
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DOI：
10.1159/000122998
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发表时间：
1980-01-01
影响因子：
4.1
通讯作者：
MOBERG, GP
中科院分区：
文献类型：
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作者：
JOHNSON, LL;MOBERG, GP
暴露在新环境中的雄性大鼠在最初的暴露中血浆皮质酮[B]显著升高。在18次暴露后，这些动物的肾上腺反应显示出显著的习惯化，但还没有完全习服。在第一次暴露于新环境后，双侧海马齿状回受损的动物的血浆B浓度显著低于对照组动物。虽然对照组的肾上腺反应在18次暴露(习惯性)后显著降低，但在试验1至18期间，齿状损伤组的肾上腺皮质对新奇应激的反应没有下降。齿状损伤的影响似乎是行为应激所特有的；齿状损伤未能改变静息水平或动物对剖腹应激和乙醚吸入的S肾上腺的反应。
Males rats exposed to a novel environment exhibited a marked rise of plasma corticosterone [B] in response to the initial exposure. These animals showed a significant but not complete habituation of their adrenal response after 18 exposures. Following their 1st exposure to a novel environment, animals with bilateral lesions in the dentate gyrus of the hippocampus had plasma B concentrations which were significantly lower than those observed for the control animals. While the control groups demonstrated a significant decrease in their adrenal response following 18 exposures (habituation), there was no decrease of the adrenocortical response to novelty stress within the dentate-lesioned group between trials 1 and 18. The effect of the dentate lesions appeared to be specific to the behavioral stress; dentate lesions failed to alter resting levels or the animal''s adrenal responses to laparotomy stress and ether inhalation.