Study on the correlation of changes of IGF-1, GH, and NGB levels and NBNA score in neonates with hypoxic ischemic encephalopathy
Study on the correlation of changes of IGF-1, GH, and NGB levels and NBNA score in neonates with hypoxic ischemic encephalopathy
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DOI：
10.26355/eurrev_201805_15078
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发表时间：
2018-05-01
影响因子：
3.3
通讯作者：
Li, Z. -G.
中科院分区：
文献类型：
--
作者：
Liu, G.;Wu, H. -W.;Li, Z. -G.
目的：探讨新生儿缺氧缺血性脑病(HIE)不同时期血清胰岛素样生长因子-1(IGF-1)、生长激素(GH)、脑红蛋白(NGB)的动态变化与新生儿行为神经测定(NBNA)评分的相关性。按诊断标准分为轻度组(35例)、中度组(19例)、重度组(6例)。同期在本院分娩的足月新生儿18例为对照组。数据用SPSS19.0统计软件(美国伊利诺伊州芝加哥SPSS Inc.)进行分析。分析HIE患者和对照组不同时期血清IGF-1、GH、NGB的动态变化及NBNA评分。结果：HIE组、HIE组、HIE
OBJECTIVE: The aim of this work was to investigate the correlation between dynamic changes of serum insulin-like growth factor 1 (IGF-1), growth hormone (GH), neuroglobin (NGB), and neonatal behavioral neurological assessment (NBNA) scores in different periods in neonates with hypoxic ischemic encephalopathy (HIE).PATIENTS AND METHODS: Sixty HIE patients in the Neonatal Department of our hospital were selected. They were divided into the mild group (35 cases), moderate group (19 cases), and severe group (six cases) according to the diagnostic criteria. During the same period, 18 neonatal patients born at term in our hospital were chosen as the control group. Data were analyzed by SPSS19.0 statistical software (SPSS Inc., Chicago, IL, USA). The dynamic changes of IGF-1, GH, and NGB in different periods, as well as NBNA scores in HIE patients and in the control group, were analyzed. Furthermore, we analyzed the degree of correlation of IGF-1, GH, and NGB in different periods as well as NBNA scores in HIE patients and in the control group.RESULTS: 1-IGF-1 levels between the three groups of HIE patients and control group had significant differences (p