HIPPOCAMPAL EVOKED-POTENTIALS AND EEG CHANGES DURING CLASSICAL-CONDITIONING IN THE RAT
HIPPOCAMPAL EVOKED-POTENTIALS AND EEG CHANGES DURING CLASSICAL-CONDITIONING IN THE RAT
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DOI：
10.1016/0013-4694(79)90033-6
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
CZOPF, J
中科院分区：
文献类型：
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作者：
BUZSAKI, G;GRASTYAN, E;CZOPF, J
采用经典条件反射范式（水，US[无条件刺激]）研究大鼠海马诱发电位（EP）和脑电图反应，并采用空间不连续的CS[条件刺激]-US排列，以分离CS和目标相关反应。在早期训练中，当定向得分较高时，音调CS通常会重置海马θ，而不是引发明确的EP。同相的活动，即。节奏变成了CS的时间锁定。随着进一步训练，定向活动（ORI）下降到预处理水平，这与短潜伏期和高电压海马电位的复发有关，与习惯化期间观察到的相似。这个高电压电位预示着动物不会再朝向CS。行为（饱足，休克US）和药理学（东莨菪碱HBr， 2 mg/kg）治疗证实了这种相关性，所有这些治疗都降低了ORI评分。海马脑电图在条件反射过程中也表现出特征性变化。对CS的ORI的频谱峰（9 c[cycles]/s）高于对US的响应（7 ~ 8 c/s）。这种相关性在会议和试验中都可以看到。这些变化与定向、注意力因素有关，而与运动相关的变量无关。
Hippocampal evoked potentials (EP) and EEG responses were studied in rats, using a classical conditioning paradigm (water, US [unconditioned stimulus]), with a spatially discontiguous CS[conditioned stimulus]-US arrangement in order to separate the CS and goal-related responses. In early training, when the orienting score was high, the tone CS, instead of eliciting a definite EP, usually reset hippocampal .theta. activity in phase, i.e., .theta. rhythm became time-locked to CS. With further training, orienting activity (ORI) decreased to the preconditioning level and this was associated with the recurrence of short-latency and high voltage hippocampal EP, similar to those observed during habituation. This high voltage EP predicted that the animal would not orient any more towards CS. This correlation was confirmed by behavioral (satiation, shock US) and by pharmacological (scopolamine HBr, 2 mg/kg) treatments, all of which reduced the ORI score. Hippocampal EEG also showed characteristic changes during conditioning. ORI towards CS was accompanied by higher frequency spectral peaks (9 c[cycles]/s) than response to US (7-8 c/s). This correlation was seen both across sessions and within trials. These changes are related to orienting, attentional factors rather than to movement-related variables.