Circulating dipeptidyl peptidase‐4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non‐alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross‐sectional study
Circulating dipeptidyl peptidase‐4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non‐alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross‐sectional study
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循环二肽基肽酶-4 活性与 2 型糖尿病和肥胖的非酒精性脂肪肝中肝细胞凋亡和纤维化的测量相关：一项双队列横断面研究
作者：
Kathryn H. Williams;Ana Júlia Vieira de Ribeiro;E. Prakoso;Anne‐Sophie Veillard;N. Shackel;B. Brooks;Y. Bu;E. Cavanagh;Jim Raleigh;S. Mclennan;G. McCaughan;F. Keane;A. Zekry;M. Gorrell;S. Twigg
二肽基肽酶-4（DPP 4）的肝内表达、循环DPP 4（cDPP 4）水平及其酶活性在非酒精性脂肪肝（NAFLD）和2型糖尿病和/或肥胖症中增加。DPP 4被认为是NAFLD进展的致病因素，但很少有研究检查cDPP 4活性与人类NAFLD严重程度之间的关联。本研究旨在检查糖尿病和/或肥胖受试者中cDPP 4活性与NAFLD中肝脏疾病严重程度的关系。
Intrahepatic expression of dipeptidyl peptidase‐4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in non‐alcoholic fatty liver disease (NAFLD) and in type 2 diabetes mellitus and/or obesity. DPP4 has been implicated as a causative factor in NAFLD progression but few studies have examined associations between cDPP4 activity and NAFLD severity in humans. This study aimed to examine the relationship of cDPP4 activity with measures of liver disease severity in NAFLD in subjects with diabetes and/or obesity.