Blood cadmium may be associated with bladder carcinogenesis: The Belgian case-control study on bladder cancer
Blood cadmium may be associated with bladder carcinogenesis: The Belgian case-control study on bladder cancer
复制标题
DOI：
10.1016/j.cdp.2006.12.001
复制
发表时间：
2007-01-01
影响因子：
--
通讯作者：
Buntinx, Frank
中科院分区：
文献类型：
--
作者：
Kellen, Eliane;Zeegers, Maurice P.;Buntinx, Frank
背景：本研究的目的是评估镉暴露与膀胱癌风险之间的关系。方法：我们在比利时进行了一项病例对照研究，测量了172例膀胱病例和359例人群对照的血液镉水平。数据经对数变换后以四分位数进行分析。分界点是根据对照组的水平确定的。采用Logistic回归计算膀胱癌发生的优势比（ORs），并给出相应的95%可信区间（95% CI）。结果：在调整性别、年龄和职业暴露于多环芳烃或芳香胺后，比较最高和最低分值，镉的or为8.3 (95% Cl 5.0-13.8) （p，趋势< 0.001）。吸烟的额外调整（当前吸烟状况、吸烟年数和每天吸烟的数量）降低了OR，但它仍然非常显著（OR: 5.7; 95% Cl 3.3-9.9）。结论：我们的研究表明，镉暴露增加的个体患膀胱癌的风险增加。未来的研究应通过研究更多的膀胱癌患者，并通过收集有关终身职业、居住和环境暴露的广泛信息来扩大这一调查，以阐明镉在膀胱癌中的作用。(c) 2007年国际预防肿瘤学会。Elsevier Ltd.出版。版权所有。
Background: The aim of this study was to assess the relationship between exposure to cadmium and bladder cancer risk. Methods: We conducted a case-control study in Belgium and measured the blood levels of cadmium in 172 bladder cases and 359 population controls. The data were analyzed as tertiles after logarithmic transformation. Cut-off points were based on the levels among the controls. Logistic regression was performed to calculate odds ratios (ORs) for bladder cancer occurrence with corresponding 95% confidence intervals (95% CI). Results: After adjustment for sex, age, and occupational exposure to PAHs or aromatic amines, the OR for cadmium was 8.3 (95% Cl 5.0-13.8) comparing the highest to the lowest tertile (p, for trend < 0.001). Additional adjustment for smoking (current cigarette smoking status, years of cigarette smoking and number of cigarettes smoked per day) decreased the OR, however it remained strongly significant (OR: 5.7; 95% Cl 3.3-9.9). Conclusion: Our study suggests that individuals with increased exposure to cadmium have an increased risk of bladder cancer. Future studies should expand on this investigation by studying a larger number of bladder cancer patients and by collecting extensive information on the lifetime occupational, residential, and environmental exposures to clarify the role of cadmium in bladder cancer. (c) 2007 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.