The use of OP-1 in femoral impaction grafting in a sheep model
The use of OP-1 in femoral impaction grafting in a sheep model
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DOI：
10.1016/j.orthres.2004.01.005
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发表时间：
2004-09-01
影响因子：
2.8
通讯作者：
Toth, C
中科院分区：
文献类型：
--
作者：
McGee, MA;Findlay, DM;Toth, C
本初步研究的目的是在绵羊骨水泥型半髋关节置换术模型中，检查单独使用同种异体骨（对照组）或使用含有骨形态发生蛋白OP-1（BMP-7）的同种异体骨（OP-1组）打入股骨的骨移植物结合情况。分别于第6、18、26周每组处死2只羊。6周时，两组均明显可见成功的骨移植物结合，但OP-1组的移植物吸收更广泛。OP-1组在6周时有1例股骨柄过度下沉。到18周时，OP-1组中出现了新骨的重塑和小梁形成，但对照组中似乎进展不快。到26周，移植床中的骨重建。这项小型研究的结果表明，OP-1促进初始移植物吸收，从而加速股骨嵌塞移植中的骨移植物结合和重塑。1例股骨柄下沉可能与OP-1组中观察到的早期再吸收相关，并强调需要进一步研究，在BNIP用于髋关节翻修术中的股骨打入移植之前，检查剂量反应并使用股骨柄移动的精确测量。(C)2004骨科研究学会。由爱思唯尔有限公司出版。保留所有权利。
The aim of this pilot study was to examine bone graft incorporation in femurs impacted with allograft bone alone (control group) or with allograft containing the bone morphogenetic protein OP-1 (BMP-7) (OP-1 group) in a sheep model of cemented hemiarthroplasty. Two sheep in each group were sacrificed at 6, 18 and 26 weeks. Successful bone graft incorporation was evident in both groups by six weeks but in the OP-1 group, there had been more extensive resorption of the graft. There was one case of excessive stem subsidence in the OP-1 group at six weeks. By 18 weeks, there was remodelling and trabeculation of the new bone in the OP-1 group, but this appeared less advanced in the control group. By 26 weeks, there was remodelling of bone in the graft bed. The results of this small study suggest that OP-1 promotes initial graft resorption, thus hastening bone graft incorporation and remodelling in femoral impaction grafting. The one case of stem subsidence may be associated with the early resorption seen in the OP-1 group and reinforces the need for further studies, examining dose response and using precise measures of stem movement, before this BNIP is used in femoral impaction grafting at revision hip arthroplasty. (C) 2004 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.